sodium (6R,7R)-7-({[1-(4-chlorophenyl)cyclopentyl]carbonyl}amino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Base Information

Chemical Name:sodium (6R,7R)-7-({[1-(4-chlorophenyl)cyclopentyl]carbonyl}amino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:143407-73-2
Molecular Formula:C₂₀H₂₀ClN₂O₄S*Na
Molecular Weight:442.899
Hs Code.:
Mol file:143407-73-2.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of sodium (6R,7R)-7-({[1-(4-chlorophenyl)cyclopentyl]carbonyl}amino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Chemical Property:

Vapor Pressure:1.31E-22mmHg at 25°C
Boiling Point:733.8°Cat760mmHg
Flash Point:397.6°C
Density:g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of sodium (6R,7R)-7-({[1-(4-chlorophenyl)cyclopentyl]carbonyl}amino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 4 articles about sodium (6R,7R)-7-({[1-(4-chlorophenyl)cyclopentyl]carbonyl}amino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.1%

: 22252-43-3,26395-99-3,70287-30-8,72059-35-9
3-deacetyloxy-7-aminocephalosporanic acid

: 71501-44-5
1-(4-chlorophenyl)cyclopentane-1-carboxylic acid chloride

: 143407-73-2
Sodium; (6R,7R)-7-{[1-(4-chloro-phenyl)-cyclopentanecarbonyl]-amino}-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In water; acetone; at 0 - 20 ℃; for 6h;
DOI:10.1007/BF00766460

Reference yield:

: 64399-26-4
1-(4-chlorophenyl)cyclopentanecarboxylic acid

: 143407-73-2
Sodium; (6R,7R)-7-{[1-(4-chloro-phenyl)-cyclopentanecarbonyl]-amino}-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 75.5 percent / KOH / various solvent(s) / 12 h / Heating

2: 1.) triethylamine, chlorocarbonic acid ethyl ester, 2.) NaHCO₃ / 1.) acetone, from 0 deg C, 30 min, to RT, 2 h, 2.) acetone, water, 4 h

With potassium hydroxide; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; In various solvent(s);
DOI:10.1007/BF00766460

Reference yield:

: 80789-69-1
1-(4-chlorophenyl)cyclopentane-1-carboxylic acid

: 143407-73-2
Sodium; (6R,7R)-7-{[1-(4-chloro-phenyl)-cyclopentanecarbonyl]-amino}-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 60.1 percent / SOCl₂ / benzene / 8 h / Heating

2: 30.1 percent / NaHCO₃ / acetone; H₂O / 6 h / 0 - 20 °C

With thionyl chloride; sodium hydrogencarbonate; In water; acetone; benzene;
DOI:10.1007/BF00766460