4-[(1,4-Dioxaspiro[4.5]decan-6-yl)methyl]phenol

Base Information

Chemical Name:4-[(1,4-Dioxaspiro[4.5]decan-6-yl)methyl]phenol
CAS No.:80826-41-1
Molecular Formula:C15H20O3
Molecular Weight:248.322
Hs Code.:
DSSTox Substance ID:DTXSID00575324

Synonyms:80826-41-1;4-[(1,4-Dioxaspiro[4.5]decan-6-yl)methyl]phenol;DTXSID00575324

Suppliers and Price of 4-[(1,4-Dioxaspiro[4.5]decan-6-yl)methyl]phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-[(1,4-Dioxaspiro[4.5]decan-6-yl)methyl]phenol

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:248.14124450
Heavy Atom Count:18
Complexity:265

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2(C(C1)CC3=CC=C(C=C3)O)OCCO2

Technology Process of 4-[(1,4-Dioxaspiro[4.5]decan-6-yl)methyl]phenol

There total 5 articles about 4-[(1,4-Dioxaspiro[4.5]decan-6-yl)methyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.5%

: 22081-10-3
2-(4-Hydroxybenzyl)-1-cyclohexanone

: 107-21-1
ethylene glycol

: 80826-41-1
2-(4-hydroxybenzyl)-1-cyclohexanone ethylene acetal

Guidance literature:: Heating;
DOI:10.1135/cccc19812573

Reference yield:

: 1125-99-1
1-(1-Cyclohexen-1-yl)pyrrolidine

: 80826-41-1
2-(4-hydroxybenzyl)-1-cyclohexanone ethylene acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 2) H₂O / 1) dioxane, 120 deg C, 5 h, 2) dioxane, reflux, 1 h

2: 55.2 percent / Ac₂O, azeotropic HBr in H₂O / 4 h / 140 °C

3: 90.5 percent / p-TsOH / benzene / 6 h / Heating; azeotropic dist.

With water; hydrogen bromide; acetic anhydride; toluene-4-sulfonic acid; In benzene;
DOI:10.1002/hlca.19940770507

Reference yield:

: 37722-64-8
2-(4-methoxybenzyl)cyclohexan-1-one

: 80826-41-1
2-(4-hydroxybenzyl)-1-cyclohexanone ethylene acetal

Guidance literature:: Multi-step reaction with 2 steps

1: 55.2 percent / Ac₂O, azeotropic HBr in H₂O / 4 h / 140 °C

2: 90.5 percent / p-TsOH / benzene / 6 h / Heating; azeotropic dist.

With hydrogen bromide; acetic anhydride; toluene-4-sulfonic acid; In benzene;
DOI:10.1002/hlca.19940770507