(4,4-Difluorocyclohexyl)methanamine HCl

Base Information

• Chemical Name: (4,4-Difluorocyclohexyl)methanamine HCl
• CAS No.: 809273-65-2
• Molecular Formula: C₇H₁₃F₂N*ClH
• Molecular Weight: 185.645
• Hs Code.: 2921300090
• Mol file: 809273-65-2.mol

Synonyms:(4,4-difluorocyclohexyl)methanamine hydrochloride;HT704;(4,4-Difluorocyclohexyl)methanamine HCl;

Chemical Property of (4,4-Difluorocyclohexyl)methanamine HCl

Chemical Property:

• Vapor Pressure: 0.13mmHg at 25°C
• Boiling Point: 214.3oC at 760 mmHg
• Flash Point: 83.4oC
• PSA: 26.02000
• LogP: 3.27290

Purity/Quality:

98%min ^*data from raw suppliers

(4,4-Difluorocyclohexyl)methanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (4,4-Difluorocyclohexyl)methanamine hcl

Technology Process of (4,4-Difluorocyclohexyl)methanamine HCl

There total 2 articles about (4,4-Difluorocyclohexyl)methanamine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl (4,4-difluorocyclohexyl)methylcarbamate (809273-64-1) → (4,4-difluorocyclohexane)methylamine hydrochloride (809273-65-2)

Guidance literature:

With hydrogenchloride; acetic acid; at 20 ℃; for 2h;

Reference yield:

(4-oxo-cyclohexylmethyl)-carbamic acid tert-butyl ester (809273-70-9) → (4,4-difluorocyclohexane)methylamine hydrochloride (809273-65-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 0 - 20 °C

2: hydrogenchloride; acetic acid / 2 h / 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; acetic acid; In dichloromethane;

Reference yield: 71.0%

(4,4-difluorocyclohexane)methylamine hydrochloride (809273-65-2) + benzaldehyde (100-52-7) → N-benzyl-1-(4,4-difluorocyclohexyl)methanamine

Guidance literature:

(4,4-difluorocyclohexane)methylamine hydrochloride; benzaldehyde; With magnesium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00539

upstream raw materials:

tert-butyl (4,4-difluorocyclohexyl)methylcarbamate

(4-oxo-cyclohexylmethyl)-carbamic acid tert-butyl ester

Refernces

• 1、 -. "Benzimidazole Derivatives, Compositions Containing Them, Preparation Thereof and Uses Thereof". Page/Page column 19. . Retrieved 2008/12/08.
• 2、 -. "COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF III". Page/Page column 32. . Retrieved 2008/06/13.