Fenyramidol

Base Information

• Chemical Name: Fenyramidol
• CAS No.: 553-69-5
• Deprecated CAS: 51550-74-4
• Molecular Formula: C13H14 N2 O
• Molecular Weight: 214.267
• European Community (EC) Number: 209-044-7
• NSC Number: 23634
• UNII: R3V02WL7O3
• DSSTox Substance ID: DTXSID00862185
• Nikkaji Number: J9.415C
• Wikipedia: Fenyramidol
• Wikidata: Q5443698
• NCI Thesaurus Code: C84054
• Metabolomics Workbench ID: 154225
• ChEMBL ID: CHEMBL1697767
• Mol file: 553-69-5.mol

Synonyms:2-(beta-hydroxyphenethylamino)pyridine hydrochloride;phenyramidol

Chemical Property of Fenyramidol

Chemical Property:

• Vapor Pressure: 1.48E-06mmHg at 25°C
• Melting Point: 82-85°
• Refractive Index: 1.6450 (estimate)
• Boiling Point: 383.2°Cat760mmHg
• PKA: 5.85(at 25℃)
• Flash Point: 185.5°C
• PSA: 45.15000
• Density: 1.206g/cm³
• LogP: 2.30010
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 214.110613074
• Heavy Atom Count: 16
• Complexity: 192

Purity/Quality:

99% ^*data from raw suppliers

(±)-Phenyramidol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CNC2=CC=CC=N2)O
• Recent ClinicalTrials: Bioequivalence Study of Feniramidol HCl 400 mg Film Tablet (Pharmactive, Turkey) Under Fed Conditions
• Uses: (±)-Phenyramidol can be used in biological study of preparation of nitric oxide releasing prodrugs useful in the treatment of diseases. It is also a muscle relaxant drug.

Technology Process of Fenyramidol

There total 12 articles about Fenyramidol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ phenyramidol (553-69-5)

Guidance literature:

With lithium aluminium tetrahydride; 1,2-dimethoxyethane;

DOI:10.1021/ja01525a061

Reference yield:

styrene oxide (96-09-3) + Natrium-Verbindung des [2]Pyridylamins (40825-17-0) → phenyramidol (553-69-5)

Guidance literature:

With 1,2-dimethoxyethane; ammonia;

DOI:10.1021/ja01525a062

Reference yield:

2-bromo-pyridine (109-04-6) + 2-Amino-1-phenylethanol (7568-93-6,1936-63-6) → phenyramidol (553-69-5)

Guidance literature:

at 140 ℃; for 48h;

DOI:10.1039/c1nj20584f

upstream raw materials:

styrene oxide

Natrium-Verbindung des [2]Pyridylamins

1-phenyl-2-[2]pyridylamino-ethanone

2-Hydroxy-1-phenyl-2-(pyridin-2-ylamino)-ethanone

Downstream raw materials:

imidazole-1-carboxylic acid 1-phenyl-2-(pyridin-2-ylamino)-ethyl ester

Acetic acid (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[1-phenyl-2-(pyridin-2-ylamino)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester

3-phenyl-2,3-dihydroimidazo[1,2-a]pyridine

2-(1-methyl-1H-[2]pyridylidenamino)-1-phenyl-ethanol; hydriodide

Refernces

• 1、 Chmielewski, Marcin K.,Tykarska, Ewa,Markiewicz, Wojciech T.,Rypniewski, Wojciech. "Engineering N-(2-pyridyl)aminoethyl alcohols as potential precursors of thermolabile protecting groups". experimental part. p. 603 - 612. Retrieved 2012/05/04.