Methyl 4-amino-3-(4-chlorophenyl)-1,2-thiazole-5-carboxylate

Base Information

Chemical Name:Methyl 4-amino-3-(4-chlorophenyl)-1,2-thiazole-5-carboxylate
CAS No.:82424-59-7
Molecular Formula:C11H9ClN2O2S
Molecular Weight:268.724
Hs Code.:
DSSTox Substance ID:DTXSID10517371
Wikidata:Q82379340

Synonyms:82424-59-7;methyl 4-amino-3-(4-chlorophenyl)-1,2-thiazole-5-carboxylate;SCHEMBL10999906;DTXSID10517371;RWOYZGJEZNTZJG-UHFFFAOYSA-N;AKOS014977959;F1907-8849;methyl 4-amino-3-(4-chlorophenyl)isothiazole-5-carboxylate;4-amino-3-(4-chloro-phenyl)-isothiazole-5-carboxylic acid methyl ester

Suppliers and Price of Methyl 4-amino-3-(4-chlorophenyl)-1,2-thiazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Methyl 4-amino-3-(4-chlorophenyl)-1,2-thiazole-5-carboxylate

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:268.0073264
Heavy Atom Count:17
Complexity:285

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C(C(=NS1)C2=CC=C(C=C2)Cl)N

Technology Process of Methyl 4-amino-3-(4-chlorophenyl)-1,2-thiazole-5-carboxylate

There total 2 articles about Methyl 4-amino-3-(4-chlorophenyl)-1,2-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₅H₁₁ClN₂O₃S

: 2365-48-2
Methyl thioglycolate

: 82424-59-7
4-amino-3-(4-chloro-phenyl)-isothiazole-5-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 4h;
DOI:10.1016/j.ejmech.2016.09.075

Reference yield:

: sodium salt of 2-(4-chlorphenyl)-2-hydroximinoacetonitrile

: 82424-59-7
4-amino-3-(4-chloro-phenyl)-isothiazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 0.25 h / 75 °C

2: triethylamine / methanol / 4 h / 20 °C

With triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.09.075