2-Thiophenepropanoic acid,R-[[2-butyl-1-[(4-carboxy-2-chlorophenyl) methyl]-1H-imidazol-5-yl]methylene]-,(RE)-

Base Information

Chemical Name:2-Thiophenepropanoic acid,R-[[2-butyl-1-[(4-carboxy-2-chlorophenyl) methyl]-1H-imidazol-5-yl]methylene]-,(RE)-
CAS No.:133485-77-5
Molecular Formula:C₂₃H₂₃ClN₂O₄S
Molecular Weight:458.966
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Thiophenepropanoic acid,R-[[2-butyl-1-[(4-carboxy-2-chlorophenyl) methyl]-1H-imidazol-5-yl]methylene]-,(RE)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Thiophenepropanoic acid,R-[[2-butyl-1-[(4-carboxy-2-chlorophenyl) methyl]-1H-imidazol-5-yl]methylene]-,(RE)-

There total 9 articles about 2-Thiophenepropanoic acid,R-[[2-butyl-1-[(4-carboxy-2-chlorophenyl) methyl]-1H-imidazol-5-yl]methylene]-,(RE)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[2-Butyl-5-((E)-2-ethoxycarbonyl-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-3-chloro-benzoic acid methyl ester

: 133485-77-5
SKF 108834

Guidance literature:: With sodium hydroxide; In ethanol; for 17h; Ambient temperature;
DOI:10.1021/jm00065a011

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 133485-77-5
SKF 108834

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine; benzoic acid / cyclohexane / 20 h / Heating

2: sodium tetrahydroborate / ethanol / 0 °C

3: potassium hydroxide / ethanol / 48 h / Ambient temperature

4: piperidine; benzoic acid / toluene / 18 h / Heating

5: sodium hydroxide / ethanol / 17 h / Ambient temperature

With piperidine; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; benzoic acid; In ethanol; cyclohexane; toluene;
DOI:10.1021/jm00065a011

Reference yield:

: 30313-06-5
diethyl 2-(thiophen-2-ylmethylene)malonate

: 133485-77-5
SKF 108834

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol / 0 °C

2: potassium hydroxide / ethanol / 48 h / Ambient temperature

3: piperidine; benzoic acid / toluene / 18 h / Heating

4: sodium hydroxide / ethanol / 17 h / Ambient temperature

With piperidine; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; benzoic acid; In ethanol; toluene;
DOI:10.1021/jm00065a011