2,6-Diisopropoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide

Base Information

Chemical Name:2,6-Diisopropoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide
CAS No.:82952-66-7
Molecular Formula:C₂₀H₃₂N₂O₃
Molecular Weight:348.486
Hs Code.:
DSSTox Substance ID:DTXSID301160913
Nikkaji Number:J386.205D
ChEMBL ID:CHEMBL1193500

Synonyms:CHEMBL1193500;DTXSID301160913;2,6-Diisopropoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide;N-[(1-Ethyl-2-pyrrolidinyl)methyl]-2,6-bis(1-methylethoxy)benzamide;82952-66-7

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Chemical Property of 2,6-Diisopropoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:348.24129289
Heavy Atom Count:25
Complexity:396

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=C(C=CC=C2OC(C)C)OC(C)C

Technology Process of 2,6-Diisopropoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide

There total 3 articles about 2,6-Diisopropoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 303-07-1
2,6-Dihydroxybenzoic acid

: 82952-66-7
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2,6-diisopropoxy-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃, NaI / dimethylformamide / 72 h / Heating

2: water, KOH / butan-1-ol / 18 h / Heating

3: SOCl₂ / toluene / 1 h / Heating

4: butan-2-one / 2 h / Ambient temperature

With potassium hydroxide; thionyl chloride; water; potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; toluene; butanone; butan-1-ol;
DOI:10.1021/jm00353a003

Reference yield:

: 79128-15-7
2,6-di(isopropoxy)benzoic acid

: 82952-66-7
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2,6-diisopropoxy-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / toluene / 1 h / Heating

2: butan-2-one / 2 h / Ambient temperature

With thionyl chloride; In toluene; butanone;
DOI:10.1021/jm00353a003

Reference yield:

: 93157-24-5
2,6-Diisopropyloxy-benzoesaeure-isopropylester

: 82952-66-7
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-2,6-diisopropoxy-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: water, KOH / butan-1-ol / 18 h / Heating

2: SOCl₂ / toluene / 1 h / Heating

3: butan-2-one / 2 h / Ambient temperature

With potassium hydroxide; thionyl chloride; water; In toluene; butanone; butan-1-ol;
DOI:10.1021/jm00353a003