303-07-1Relevant articles and documents
Quantitation of the hydroxyl radical adducts of salicylic acid by micellar electrokinetic capillary chromatography: Oxidizing species formed by a Fenton reaction
Tomita,Okuyama,Watanabe,Watanabe
, p. 428 - 433 (1994)
There has been controversy concerning the products formed by a Fenton reaction. We determined the hydroxyl radical (.OH) generated in a Fenton reaction system with no iron chelator using micellar electrokinetic capillary chromatography (MECC). The hydroxyl radical generated in this Fenton system attacked salicylic acid to produce major products of 2,3- and 2,5-dihydroxybenzoic acid (DHB), 2,3-DHB being prominent. Hydroxyl radical scavengers, such as mannitol, ethanol, thiourea and a ferric chelator, Desferal, significantly diminished the peaks for DHBs, showing production of .OH. We compared the MECC method with the electron paramagnetic resonance (EPR) spin trapping technique. The quantity of DHBs obtained by MECC increased dose-dependently up to 1 μM Fe2+ at a fixed concentration of H2O2, whereas that of the spin adduct by EPR showed a bell-shaped curve. This quantitation of .OH adducts by MECC supports the proposal that the oxidizing species formed by a Fenton reaction with no chelator is .OH. The EPR spin trapping method appears to be erroneous, particularly when iron is present at a higher concentration than hydrogen peroxide. The application of this method to the paraquat effect in vitro is demonstrated, and the possibility for analysis of .OH in vivo is also discussed.
Method for producing 2,6-dihydroxybenzoic acid
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Paragraph 0041-0052, (2019/01/16)
The invention discloses a method for producing 2,6-dihydroxybenzoic acid. The method is characterized in that in the carboxylation reaction of 2,6-dihydroxybenzoic acid, self-suction airfoil axial flow stirring is used as the stirring pattern of a carboxylation reactor, so that gas, liquid and solid phases in the reaction system of the carboxylation reaction are fully mixed and contacted; besides,a phase transfer catalyst is added in the carboxylation reaction process, homogenization of the gas-liquid-solid three-phase reaction is improved, and one-time yield of the reaction product is increased. The one-time yield of the reaction product can be increased by 5%-10% with the method.
6-sulfonate pyrimidyl salicylate compound and preparation method and application thereof
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Paragraph 0135; 0136; 0137; 0138, (2017/07/19)
The invention relates to the field of herbicides and discloses a 6-sulfonate pyrimidyl salicylate compound and a preparation method and application thereof. The compound has a structure as shown in a formula (1). The method for preparing the 6-sulfonate pyrimidyl salicylate compound comprises the steps of (1) carrying out first contact reaction on the compound as shown in a formula (2) and R2SO2Cl to obtain a compound as shown in a formula (3); and (2) carrying out second contact reaction on the compound as shown in the formula (3) and trifluoroacetic acid. The 6-sulfonate pyrimidyl salicylate compound has a good inhibition effect on acetohydroxyacid synthase, and has significant resistance inhibition effect on weeds which are resistant to an acetohydroxyacid synthase inhibitor herbicide, thereby controlling weed resistance plants caused by acetohydroxyacid synthase. The formulas are as shown in the specification.