2-(4-Bromophenyl)-4-methylmorpholine

Base Information

• Chemical Name: 2-(4-Bromophenyl)-4-methylmorpholine
• CAS No.: 83081-06-5
• Molecular Formula: C₁₁H₁₄BrNO
• Molecular Weight: 256.142
• DSSTox Substance ID: DTXSID80509223
• Mol file: 83081-06-5.mol

Synonyms:2-(4-bromophenyl)-4-methylmorpholine;83081-06-5;Morpholine, 2-(4-bromophenyl)-4-methyl-;SCHEMBL14862784;DTXSID80509223;JXMXBBJTBHSOJT-UHFFFAOYSA-N;N-methyl-2-(4'-bromophenyl)morpholine

Chemical Property of 2-(4-Bromophenyl)-4-methylmorpholine

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 255.02588
• Heavy Atom Count: 14
• Complexity: 180

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCOC(C1)C2=CC=C(C=C2)Br

Technology Process of 2-(4-Bromophenyl)-4-methylmorpholine

There total 4 articles about 2-(4-Bromophenyl)-4-methylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + 2-(4-bromophenyl)-2-oxoethyl acetate (7500-37-0) → 2-(4-Bromo-phenyl)-4-methyl-morpholine (83081-06-5)

Guidance literature:

With formic acid; at 180 ℃; for 20h;

DOI:10.1002/cber.19821150726

Reference yield: 40.0%

(2-hydroxyethyl)(methyl)amine (109-83-1) + para-bromophenacyl bromide (99-73-0,132309-76-3) → 2-(4-Bromo-phenyl)-4-methyl-morpholine (83081-06-5)

Guidance literature:

With formic acid; for 12h; Heating;

DOI:10.1002/cber.19821150726

Reference yield:

6-(4-Bromo-phenyl)-4-methyl-3,4-dihydro-2H-[1,4]oxazine → 2-(4-Bromo-phenyl)-4-methyl-morpholine (83081-06-5)

Guidance literature:

With formic acid; at 180 ℃; for 5.5h; Yield given;

DOI:10.1002/cber.19821150726

upstream raw materials:

(2-hydroxyethyl)(methyl)amine

2-(4-bromophenyl)-2-oxoethyl acetate

para-bromophenacyl bromide

Downstream raw materials:

2-(4-Bromo-phenyl)-morpholine-4-carboxylic acid ethyl ester