N-(4-aminophenyl)-N-cyclohexylacetamide

Base Information

• Chemical Name: N-(4-aminophenyl)-N-cyclohexylacetamide
• CAS No.: 83386-36-1
• Molecular Formula: C14H20N2O
• Molecular Weight: 232.32100
• Hs Code.: 2924299090
• Mol file: 83386-36-1.mol

Synonyms:N'-Cyclohexyl-N-acetyl-p-phenylendiamin;

Chemical Property of N-(4-aminophenyl)-N-cyclohexylacetamide

Chemical Property:

• Melting Point: 124 °C
• Boiling Point: 445.8±28.0 °C(Predicted)
• PKA: 14.81±0.70(Predicted)
• PSA: 46.33000
• Density: 1.136±0.06 g/cm3(Predicted)
• LogP: 3.53560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-aminophenyl)-N-cyclohexylacetamide

There total 2 articles about N-(4-aminophenyl)-N-cyclohexylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

cyclohexylamine (108-91-8,157973-60-9) + N-(4-chlorophenyl)acetamide (539-03-7) → N-(4-(cyclohexylamino)phenyl)acetamide (83386-36-1)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; lithium hexamethyldisilazane; sodium t-butanolate; In 1,4-dioxane; at 65 ℃; for 36h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/jo202358p

Reference yield:

1-bromocyclohexane (108-85-0) + N-acetyl-p-phenylenediamine (122-80-5) → N-(4-(cyclohexylamino)phenyl)acetamide (83386-36-1)

Guidance literature:

at 185 ℃;

upstream raw materials:

1-bromocyclohexane

N-acetyl-p-phenylenediamine

cyclohexylamine

N-(4-chlorophenyl)acetamide

Refernces