Pyrazine-2,5-dicarboxylic acid

Base Information

• Chemical Name: Pyrazine-2,5-dicarboxylic acid
• CAS No.: 122-05-4
• Molecular Formula: C6H4N2O4
• Molecular Weight: 168.109
• Hs Code.: 2933990090
• European Community (EC) Number: 625-778-4,850-651-7
• NSC Number: 80650
• DSSTox Substance ID: DTXSID30292178
• Nikkaji Number: J293.842A
• Wikidata: Q72503334
• Mol file: 122-05-4.mol

Synonyms:Pyrazine-2,5-dicarboxylic acid;122-05-4;2,5-Pyrazinedicarboxylic acid;MFCD01630902;MFCD00216919;205692-63-3;SCHEMBL70035;2,5-PYRAZINE-DIACID;DTXSID30292178;AMY24905;BCP23297;CS-M0630;NSC80650;NSC-80650;AKOS000279924;PB32256;SB10620;SY022756;TS-00145;FT-0651882;EN300-150129;J-004753;J-524073;Z1201621139

Chemical Property of Pyrazine-2,5-dicarboxylic acid

Chemical Property:

• Vapor Pressure: 1.67E-09mmHg at 25°C
• Melting Point: 220-230°C
• Refractive Index: 1.638
• Boiling Point: 466.5 °C at 760 mmHg
• PKA: 2.20±0.10(Predicted)
• Flash Point: 236 °C
• PSA: 100.38000
• Density: 1.665 g/cm³
• LogP: -0.12700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 2
• Exact Mass: 168.01710661
• Heavy Atom Count: 12
• Complexity: 184

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pyrazine-2,5-dicarboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=CC(=N1)C(=O)O)C(=O)O
• Uses: It is an pyrazine used for proteomics research.

Technology Process of Pyrazine-2,5-dicarboxylic acid

There total 19 articles about Pyrazine-2,5-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,5-dimethyl-pyrazine (123-32-0) → 2,5-pyrazinedicarboxylic acid (122-05-4)

Guidance literature:

With potassium permanganate; potassium hydroxide; In water; at 60 ℃; for 7h; Reagent/catalyst;

Reference yield: 40.0%

2,5-dimethyl-pyrazine (123-32-0) → 2-methylpyrazin-5-carboxylic acid (5521-55-1) + 2,5-pyrazinedicarboxylic acid (122-05-4)

Guidance literature:

With chromium(III) nitrate; In water; Ambient temperature; electrochemical oxidation on activated nickel hydroxide anode;

DOI:10.1007/BF01171298

Reference yield: 28.0%

2-(D-arabino-tetrahydroxybutyl)-5-(3,4-dihydroxy-2-sulfobutyl)pyrazine (82995-50-4) → 2,5-pyrazinedicarboxylic acid (122-05-4)

Guidance literature:

With potassium hydroxide; potassium permanganate; In water; pH=11.6;

DOI:10.1021/jo00145a034

upstream raw materials:

2,5-dimethyl-pyrazine

2-pyrazylcarboxylic acid

bromopyruvic acid

dimethyl Pyrazine-2,5-dicarboxylate

Downstream raw materials:

dimethyl Pyrazine-2,5-dicarboxylate

1,4-pyrazine

2-pyrazylcarboxylic acid

methylammonium carbonate

Refernces

• 1、 Rajappa,Sreenivasan. "-". . p. 2217. Retrieved 1978.
• 2、 Williams et al.. "-". . p. 2963. Retrieved 1972.
• 3、 Agyin, Joseph K.,Santhamma, Bindu,Roy, Sudipa S.. "Design, synthesis, and biological evaluation of bone-targeted proteasome inhibitors for multiple myeloma". . p. 6455 - 6458. Retrieved 2013.
• 4、 Mager,Berends. "-". . p. 842,847. Retrieved 1958.
• 5、 Sharefkin,Spoerri. "-". . p. 1637. Retrieved 1951.
• 6、 Krems,Spoerri. "-". . p. 527. Retrieved 1946.
• 7、 -. "SUBSTITUTED PIPERAZINE COMPOUND, AND ABSORBENT AND LIQUID ABSORBENT FOR ACIDIC GAS". Paragraph 0031; 0032; 0033. . Retrieved 2018/10/19.