methyl 5-(hydroxymethyl)pyrazine-2-carboxylate

Base Information

• Chemical Name: methyl 5-(hydroxymethyl)pyrazine-2-carboxylate
• CAS No.: 1262803-64-4
• Molecular Formula: C7H8N2O3
• Molecular Weight: 168.152
• Mol file: 1262803-64-4.mol

Synonyms:methyl 5-(hydroxymethyl)pyrazine-2-carboxylate;2-Pyrazinecarboxylic acid, 5-(hydroxymethyl)-, methyl ester

Chemical Property of methyl 5-(hydroxymethyl)pyrazine-2-carboxylate

Chemical Property:

• PSA: 72.31000
• LogP: -0.24450

Purity/Quality:

97% ^*data from raw suppliers

methyl5-(hydroxymethyl)pyrazine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-(hydroxymethyl)pyrazine-2-carboxylate

There total 5 articles about methyl 5-(hydroxymethyl)pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.6%

dimethyl Pyrazine-2,5-dicarboxylate (13051-89-3) → methyl 5-(hydroxymethyl)pyrazine-2-carboxylate (1262803-64-4)

Guidance literature:

With methanol; sodium tetrahydroborate; In dichloromethane; at 0 ℃; for 1.75h;

Reference yield: 40.0%

5-bromopyrazine-2-carboxylic acid methyl ester (210037-58-4) + (p-hydroxyphenyl)boronic acid (71597-85-8) → methyl 5-(hydroxymethyl)pyrazine-2-carboxylate (1262803-64-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,2-dimethoxyethane; water; at 110 ℃; for 0.25h; Microwave irradiation;

Reference yield:

5-formylpyrazine-2-carboxylic acid methyl ester (710322-57-9) → methyl 5-(hydroxymethyl)pyrazine-2-carboxylate (1262803-64-4)

Guidance literature:

5-formylpyrazine-2-carboxylic acid methyl ester; With sodium tetrahydroborate; In tetrahydrofuran; for 1.16667h;

With methanol; In tetrahydrofuran; for 0.333333h;

With hydrogenchloride; water; In tetrahydrofuran;

upstream raw materials:

5-formylpyrazine-2-carboxylic acid methyl ester

5-bromopyrazine-2-carboxylic acid methyl ester

(p-hydroxyphenyl)boronic acid

dimethyl Pyrazine-2,5-dicarboxylate

Downstream raw materials:

N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

methyl 5-(bromomethyl)pyrazine-2-carboxylate

C₂₄H₂₄F₅N₅O₄S

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