8-MERCAPTOGUANOSINE

Base Information

• Chemical Name: 8-MERCAPTOGUANOSINE
• CAS No.: 26001-38-7
• Molecular Formula: C10H13 N5 O5 S
• Molecular Weight: 315.31
• Hs Code.: 29389090
• Mol file: 26001-38-7.mol

Synonyms:Guanosine,8-mercapto- (7CI,8CI);8-Mercaptoguanosine;8-Thioguanosine;NSC 79216;SQ12760;

Chemical Property of 8-MERCAPTOGUANOSINE

Chemical Property:

• Vapor Pressure: 1.22E-16mmHg at 25°C
• Melting Point: >220 °C
• Refractive Index: 2.024
• Boiling Point: 595.1°Cat760mmHg
• PKA: 6.15±0.20(Predicted)
• Flash Point: 313.7°C
• PSA: 198.31000
• Density: 2.35g/cm³
• LogP: -1.81680
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Thioguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-MERCAPTOGUANOSINE

There total 9 articles about 8-MERCAPTOGUANOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

8-bromoguanosine (4016-63-1) → 8-mercapto-guanosine (26001-38-7)

Guidance literature:

With thiourea; In ethanol; for 24h; Heating;

DOI:10.1080/07328319308018564

Reference yield: 68.0%

8-bromoguanosine (4016-63-1) → 8-mercaptoguanosine (26001-38-7)

Guidance literature:

With thiourea; In ethanol; water; for 24h; Reflux;

DOI:10.1111/php.12900

Reference yield:

8-nitroguanosine → 8-aminoguanosine (3868-32-4) + 8-mercapto-guanosine (26001-38-7)

Guidance literature:

With diethylenetriaminopentaacetic acid; hydrogen sulfide; In aq. buffer; at 37 ℃; for 3h; pH=7.1;

DOI:10.1039/c4ob00868e

upstream raw materials:

8-bromoguanosine

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

2-amino-8-thioxo-1,7,8,9-tetrahydro-purin-6-one

G

Downstream raw materials:

8-(2-propenylthio)guanosine

2-amino-7-(2-propenyl)-9-β-D-ribofuranosylpurin-6(1H)-one-8-thione

G

8-Benzylthioguanosine

Refernces

• 1、 Terzic,Padovani,Balland,Artaud,Galardon. "Electrophilic sulfhydration of 8-nitro-cGMP involves sulfane sulfur". . p. 5360 - 5364. Retrieved 2014.
• 2、 Miyata, Shoma,Yamada, Takeshi,Isozaki, Tasuku,Sugimura, Hideyuki,Xu, Yao–Zhong,Suzuki, Tadashi. "Absorption Characteristics and Quantum Yields of Singlet Oxygen Generation of Thioguanosine Derivatives". . p. 677 - 684. Retrieved 2018/04/05.