Guanosine, 8-bromo-

Base Information

• Chemical Name: Guanosine, 8-bromo-
• CAS No.: 4016-63-1
• Molecular Formula: C10H12BrN5O5
• Molecular Weight: 362.14
• Hs Code.: 29389090
• Mol file: 4016-63-1.mol

Synonyms:8-Bromoguanosine;NSC 174257;NSC 79211;

Chemical Property of Guanosine, 8-bromo-

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 1.73E-17mmHg at 25°C
• Melting Point: 222°C
• Refractive Index: 1.986
• Boiling Point: 774oC at 760mmHg
• PKA: 13.00±0.70(Predicted)
• Flash Point: 421.9oC
• PSA: 159.77000
• Density: 2.62 g/cm³
• LogP: -0.93070
• Storage Temp.: ?20°C
• Solubility.: DMSO, Methanol (Sparingly), Hot Water

Purity/Quality:

98% ^*data from raw suppliers

8-Bromoguanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Guanosine, 8-bromo-

There total 4 articles about Guanosine, 8-bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

G (118-00-3) → 8-bromoguanosine (4016-63-1)

Guidance literature:

With bromine; In water; at 20 ℃;

DOI:10.1080/15257770.2018.1485932

Reference yield: 90.0%

2',3',5'.-tri-O-acetyl-8-bromoguanosine (15717-45-0) → 8-bromoguanosine (4016-63-1)

Guidance literature:

With methanol; water; triethylamine; at 71 ℃; Microwave irradiation;

DOI:10.1590/S0103-50532010000500013

Reference yield: 70.0%

→ 8-bromoguanosine (4016-63-1)

Guidance literature:

upstream raw materials:

G

2',3',5'.-tri-O-acetyl-8-bromoguanosine

Downstream raw materials:

8-methoxyguanosine

8-(2-propenylthio)guanosine

8-Methylamino-guanosin

8-(benzyloxy)guanosine

Refernces

• 1、 Das, Rabindra Nath,Kumar, Y. Pavan,Kumar, S. Arun,Schütte, Ole Mathis,Steinem, Claudia,Dash, Jyotirmayee. "Self-Assembly of a Guanosine Derivative To Form Nanostructures and Transmembrane Channels". . p. 4002 - 4005. Retrieved 2018.
• 2、 Miyata, Shoma,Yamada, Takeshi,Isozaki, Tasuku,Sugimura, Hideyuki,Xu, Yao–Zhong,Suzuki, Tadashi. "Absorption Characteristics and Quantum Yields of Singlet Oxygen Generation of Thioguanosine Derivatives". . p. 677 - 684. Retrieved 2018/04/05.