2-(4-Methoxyphenyl)-2,5-dihydrofuran

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-2,5-dihydrofuran
• CAS No.: 84132-74-1
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• DSSTox Substance ID: DTXSID90443346
• Nikkaji Number: J978.952I
• Mol file: 84132-74-1.mol

Synonyms:2-(4-methoxyphenyl)-2,5-dihydrofuran;84132-74-1;2,5-Dihydro-2-(4-methoxyphenyl)furan;Furan, 2,5-dihydro-2-(4-methoxyphenyl)-;DTXSID90443346;2-(4-methoxyphenyl)-2,5-dihydro-furan

Chemical Property of 2-(4-Methoxyphenyl)-2,5-dihydrofuran

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.083729621
• Heavy Atom Count: 13
• Complexity: 181

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2C=CCO2

Technology Process of 2-(4-Methoxyphenyl)-2,5-dihydrofuran

There total 16 articles about 2-(4-Methoxyphenyl)-2,5-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(1-allyloxyallyl)-4-methoxybenzene (309723-10-2) → 2-(4-methoxyphenyl)-2,5-dihydrofuran (84132-74-1)

Guidance literature:

With Grubbs catalyst first generation; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/1099-0690(200009)2000:18<3145::AID-EJOC3145>3.0.CO;2-B

Reference yield: 87.0%

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + (4-Methoxyphenyl)mercuric acetate (5780-90-5) → 2-(4-methoxyphenyl)-2,5-dihydrofuran (84132-74-1)

Guidance literature:

With palladium diacetate; In acetonitrile; for 12h; Ambient temperature;

DOI:10.1021/jo00262a014

Reference yield: 85.0%

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + bis(4-anisyl)iodonium triflate (141339-54-0) → 2-(4-methoxyphenyl)-2,5-dihydrofuran (84132-74-1)

Guidance literature:

With trans-di(μ-acetato)-bis[o-(di-o-tolylphosphino)benzyl]-dipalladium(II); sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.1c04120

upstream raw materials:

2,3-dihydro-2H-furan

(4-Methoxyphenyl)mercuric acetate

(p-methoxyphenyl)tri-n-butylstannane

para-iodoanisole

Downstream raw materials:

2-p-methoxyphenyltetrahydrofuran

2-(4-methoxyphenyl)-5-phenylfuran

methyl 2-methoxy-5-(5-(4-methoxyphenyl)furan-2-yl)benzoate

2-(4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)furan