2,3,5-tribromo-1-methyl-1H-indole

Base Information

• Chemical Name: 2,3,5-tribromo-1-methyl-1H-indole
• CAS No.: 70063-25-1
• Molecular Formula: C₉H₆Br₃N
• Molecular Weight: 367.865
• Mol file: 70063-25-1.mol

Synonyms:1-Methyl-2,3,5-tribromoindole;2,3,5-Tribromo-1-methyl-1H-indole; 2,3,5-Tribromo-N-methylindole; NSC 341592

Chemical Property of 2,3,5-tribromo-1-methyl-1H-indole

Chemical Property:

• Vapor Pressure: 1.33E-06mmHg at 25°C
• Boiling Point: 411.4°Cat760mmHg
• Flash Point: 202.6°C
• Density: 2.18g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,5-tribromo-1-methyl-1H-indole

There total 5 articles about 2,3,5-tribromo-1-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3,5-tribromo-1H-indole (918529-97-2) + methyl iodide (74-88-4) → 2,3,5-tribromo-1-methyl-1H-indole (70063-25-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 0.75h; cooling;

DOI:10.1021/np060406a

Reference yield: 85.0%

5-bromo-1-methyl-H-indole (10075-52-2) → 2,3,5-tribromo-1-methyl-1H-indole (70063-25-1)

Guidance literature:

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In 1,2-dichloro-ethane; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2015.01.080

Reference yield: 85.0%

methyl 2,3,5-tribromo-1H-indole-1-carboxylate (918529-93-8) + methyl iodide (74-88-4) → 2,3,5-tribromo-1-methyl-1H-indole (70063-25-1)

Guidance literature:

methyl 2,3,5-tribromo-1H-indole-1-carboxylate; With methanol; sodium hydride; In tetrahydrofuran; for 2h; Inert atmosphere; Reflux;

methyl iodide; With sodium hydride; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.201400032

upstream raw materials:

2,3,5-tribromo-1H-indole

methyl iodide

1-indoline

2,3-dihydroindole-1-carboxylic acid methyl ester