2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol

Base Information

• Chemical Name: 2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol
• CAS No.: 842149-46-6
• Molecular Formula: C10H9ClN6O2
• Molecular Weight: 280.673
• Hs Code.: 2934999090
• Mol file: 842149-46-6.mol

Synonyms:2-(4-Amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol;

Chemical Property of 2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol

Chemical Property:

• Boiling Point: 682.9±65.0 °C(Predicted)
• PKA: 6.70±0.40(Predicted)
• PSA: 115.88000
• Density: 1.91±0.1 g/cm3(Predicted)
• LogP: 2.02360

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(4-Amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol

There total 11 articles about 2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine (842144-07-4) → 2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol (842149-46-6)

Guidance literature:

4-(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine; With isopropyl magnesium chloride; Trimethyl borate; In diethyl ether; at -75 - 0 ℃; for 19.1667h;

With sodium hydroxide; dihydrogen peroxide; In diethyl ether; water; at 40 ℃;

Reference yield: 88.0%

4-(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine → 2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol (842149-46-6)

Guidance literature:

4-(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine; With isopropyl magnesium chloride; In tetrahydrofuran; diethyl ether; at -75 - -70 ℃; for 0.166667h; Cooling with acetone-dry ice;

With Trimethyl borate; In tetrahydrofuran; diethyl ether; at 20 ℃; for 19h; Cooling with acetone-dry ice;

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; more than 3 stages;

Reference yield:

4-(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine (842144-07-4) + Trimethyl borate (121-43-7,63156-11-6) → 2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-ol (842149-46-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; isopropylmagnesium chloride; ethyl acetate; toluene;

upstream raw materials:

4-(7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine

Trimethyl borate

ethyl-(3-bromo-5-nitropyridin-4-yl)amine

5-bromo-2-chloro-N₄-ethylpyridine-3,4-diamine

Downstream raw materials:

1,1-dimethylethyl (3S)-3-({[2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]oxy}methyl)-1-piperidinecarboxylate

1,1-dimethylethyl (3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl]oxy}propyl)carbamate

4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[3-({2-[4-(methoxy)phenyl]ethyl}amino)propyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol

GSK₆₉₀₆₉₃

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