2-(4-BROMOPENTYL)-1H-ISIONDOLE-1,3(2H)DIONE

Base Information

• Chemical Name: 2-(4-BROMOPENTYL)-1H-ISIONDOLE-1,3(2H)DIONE
• CAS No.: 59353-62-7
• Molecular Formula: C13H14 Br N O2
• Molecular Weight: 296.164
• Mol file: 59353-62-7.mol

Synonyms:Phthalimide,N-(4-bromopentyl)- (6CI); 2-(4-Bromopentyl)-1,3-isoindolinedione;2-(4-Bromopentyl)isoindole-1,3-dione; 2-Bromo-5-phthalimidopentane;4-Bromo-1-phthalimidopentane; NSC 46819

Chemical Property of 2-(4-BROMOPENTYL)-1H-ISIONDOLE-1,3(2H)DIONE

Chemical Property:

• Vapor Pressure: 3.5E-06mmHg at 25°C
• Boiling Point: 386.6°C at 760 mmHg
• PKA: -2.15±0.20(Predicted)
• Flash Point: 187.6°C
• PSA: 37.38000
• Density: 1.457g/cm³
• LogP: 2.78410
• Solubility.: DCM, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-5-phthalimidopentane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-5-phthalimidopentane is an intermediate in the synthesis of Primaquine (P733500), an antimalarial agent.

Technology Process of 2-(4-BROMOPENTYL)-1H-ISIONDOLE-1,3(2H)DIONE

There total 12 articles about 2-(4-BROMOPENTYL)-1H-ISIONDOLE-1,3(2H)DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

potassium phtalimide (1074-82-4) + 1,4-dibromopentane (626-87-9) → 4-bromo-1-phthalimidopentane (59353-62-7)

Guidance literature:

In 1,1,1-trichloroethane; at 60 ℃; for 24h;

DOI:10.1002/cmdc.202000740

Reference yield: 98.71%

2-(pent-4-enyl)-isoindoline-1,3-dione (7736-25-6) → 4-bromo-1-phthalimidopentane (59353-62-7)

Guidance literature:

With hydrogen bromide; In N,N,N,N,N,N-hexamethylphosphoric triamide; at -10 - 20 ℃; for 6h; Solvent;

Reference yield:

phthalimide (136918-14-4,85-41-6) + potassium phtalimide (1074-82-4) + 1,4-dibromopentane (626-87-9) → 4-bromo-1-phthalimidopentane (59353-62-7)

Guidance literature:

In acetone;

upstream raw materials:

2-(pent-4-enyl)-isoindoline-1,3-dione

potassium phtalimide

1,4-dibromopentane

bromopentene

Downstream raw materials:

N-(4-diethylamino-pentyl)-phthalimide

6-hydroxy-8-(1-methyl-4-phthalimidobutylamino)cinnoline

2-<4-<(5-methoxy-7-benzofuranyl)amino>pentyl>-1H-isoindole-1,3(2H)-dione

2-[4-(7-Bromo-3,4-dimethoxy-naphthalen-1-ylamino)-pentyl]-isoindole-1,3-dione