7736-25-6

Usage

Uses

Used in Organic Synthesis:
2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione is used as a building block in organic synthesis for its unique structural features, enabling the creation of a variety of complex organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione is utilized as a key component in the development of new drugs, leveraging its potential biological activities for therapeutic applications.
Used in Agricultural Chemicals:
2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione is also used in the agricultural chemical sector, where it may contribute to the formulation of effective pesticides or other agrochemicals.
Used in Anti-Cancer Research:
2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione is studied for its potential as an anti-cancer agent, with ongoing research exploring its effects on various types of cancer cells.
Used in Anti-Inflammatory Applications:
2-(pent-4-en-1-yl)-1H-isoindole-1,3(2H)-dione is also being investigated for its anti-inflammatory properties, which could lead to its use in the development of treatments for inflammatory conditions.

Upstream product

• 1074-82-4 potassium phtalimide 
• 1119-51-3 bromopentene 
• 136918-14-4 phthalimide 
• 821-09-0 n-Pent-4-enyl alcohol 
• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 72824-04-5 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 5390-04-5 pent-1-yn-5-ol 
• 124-63-0 methanesulfonyl chloride 
• 4443-26-9 6-phthalimidohexanoic acid 
• 6097-07-0 N-(pent-4-ynyl)phthalimide 
• 954-81-4 N-(5-bromopentyl)phthalimide 
• 19300-54-0 toluene-4-sulfonic acid pent-4-enyl ester 
• 145732-26-9 2-(allylthio)-1,1,1,3,3,3-hexamethyl-2-(trimethylsilyl)trisilane 
• 928-50-7 5-chloropent-1-ene 

Downstream Products

• 93272-49-2 2-(3-(oxiran-2-yl)propyl)isoindoline-1,3-dione 
• 81097-24-7 N-tosyl-(4-pentenyl)amine 
• 18060-79-2 4-pentenyl isothiocyanate 
• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 1047673-23-3 C₂₂H₂₄N₂O₆S 
• 1234714-98-7 C₂₀H₂₀FNO₃ 
• 1234715-00-4 C₂₁H₂₁NO₄ 
• 1234715-01-5 C₂₂H₁₉F₆NO₃ 
• 1234714-99-8 C₂₂H₂₃NO₅ 
• 1234714-84-1 C₂₀H₂₁NO₃ 
• 1234715-14-0 C₁₉H₁₈FNO₃ 
• 1234714-92-1 C₂₁H₂₁NO₄ 
• 1234714-93-2 C₂₂H₂₃NO₄ 
• 1234714-94-3 C₂₃H₂₅NO₄ 

Relevant academic research and scientific papers

Synthesis of a library of tricyclic azepinoisoindolinones

Hydrozirconation of 1-hexyne, the addition to in situ prepared N-acyliminium species, and ring-closing metathesis (RCM) were key steps in the preparation of a tricyclic isoindolinone scaffold. An unusual alkene isomerization process during the RCM was identified and studied in some detail. Chemical diversification for library synthesis was achieved by a subsequent alkene epoxidation and zinc-mediated aminolysis reaction. The resulting library products provided selective hits among a large number of high-throughput screens reported in PubChem, thus illustrating the utility of the novel scaffold.

A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF

The present invention relates to a class of bifunctional chimeric heterocyclic compounds for targeted degradation of androgen receptors and use thereof, and specifically provides a compound of formula (I), or an isotopic compound thereof, or an optical isomer thereof, or a tautomer thereof, or a pharmacologically acceptable salt thereof, or a prodrug thereof, or a solvate thereof, wherein ARB is an androgen receptor recognition/binding part, L is a link part, and U is a ubiquitin protease recognition/binding part; and the three parts are connected by means of chemical bonds. The compound can perform the targeted degradation on androgen receptors in prostate cancer cells, and suppress the proliferation of the prostate cancer cells, and also show good metabolic stability and pharmacokinetic properties. The compound has good application prospect in the preparation of targeted chimeras for protein degradation of androgen receptors and in the preparation of drugs for treating the related diseases regulated by the androgen receptors.

Nickel-Catalyzed Hydrosilylation of Terminal Alkenes with Primary Silanes via Electrophilic Silicon-Hydrogen Bond Activation

We report a simple and effective nickel-based catalytic system, NiCl2·6H2O/tBuOK, for the electrophilically activated hydrosilylation of terminal alkenes with primary silanes. This protocol provides excellent performance under mild reaction conditions: ex

Merging Halogen-Atom Transfer (XAT) and Cobalt Catalysis to Override E2-Selectivity in the Elimination of Alkyl Halides: A Mild Route towardcontra-Thermodynamic Olefins

We report here a mechanistically distinct tactic to carry E2-type eliminations on alkyl halides. This strategy exploits the interplay of α-aminoalkyl radical-mediated halogen-atom transfer (XAT) with desaturative cobalt catalysis. The methodology is high-yielding, tolerates many functionalities, and was used to access industrially relevant materials. In contrast to thermal E2 eliminations where unsymmetrical substrates give regioisomeric mixtures, this approach enables, by fine-tuning of the electronic and steric properties of the cobalt catalyst, to obtain high olefin positional selectivity. This unprecedented mechanistic feature has allowed access tocontra-thermodynamic olefins, elusive by E2 eliminations.

Cross-Module Enoylreduction in the Azalomycin F Polyketide Synthase

The colinearity of canonical modular polyketide synthases, which creates a direct link between multienzyme structure and the chemical structure of the biosynthetic end-product, has become a cornerstone of knowledge-based genome mining. Herein, we report genetic and enzymatic evidence for the remarkable role of an enoylreductase in the polyketide synthase for azalomycin F biosynthesis. This internal enoylreductase domain, previously identified as acting only in the second of two chain extension cycles on an initial iterative module, is shown to also catalyze enoylreduction in trans within the next module. The mechanism for this rare deviation from colinearity appears to involve direct cross-modular interaction of the reductase with the longer acyl chain, rather than back transfer of the substrate into the iterative module, suggesting an additional and surprising plasticity in natural PKS assembly-line catalysis.

Highly selective hydrosilylation of equilibrating allylic azides

The Pt-catalyzed hydrosilylation of equilibrating allylic azides is reported. The reaction provides only one out of four possible hydrosilylation products in good yields and with very high chemoselectivity (alk-1-enevs.alk-2-ene), regioselectivity (linearvs.branched), and excellent functional group tolerance.

Synthesis method of 3-azidopropylsilane

The invention discloses a synthetic method of 3-azidopropylsilane, wherein the method comprises the steps: firstly, allyl azide is synthesized by allyl bromide, and because the allyl azide is easy togenerate [3,3] rearrangement reaction at room temperatur

APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS AND USES THEREOF

Described herein are ASK1 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of blood disease, autoimmune disorders, pulmonary disorders, hypertension, inflammatory diseases, fibrotic diseases, diabetes, diabetic nephropathy, renal diseases, respiratory diseases, cardiovascular diseases, acute lung injuries, acute or chronic liver diseases, and neurodegenerative diseases.

Intramolecular Mannich and Michael Annulation Reactions of Lactam Derivatives Bearing Enals to Afford Bicyclic N-Heterocycles

Acid-catalyzed intramolecular vinylogous Mannich reactions and intramolecular Michael reactions affording pyrrolizinone-fused N-heterocycles from hydroxylactam derivatives bearing enals have been developed. Depending on the substituent on the hydroxylacta

A Peptide Backbone Stapling Strategy Enabled by the Multicomponent Incorporation of Amide N-Substituents

The multicomponent backbone N-modification of peptides on solid-phase is presented as a powerful and general method to enable peptide stapling at the backbone instead of the side chains. This work shows that a variety of functionalized N-substituents suitable for backbone stapling can be readily introduced by means of on-resin Ugi multicomponent reactions conducted during solid-phase peptide synthesis. Diverse macrocyclization chemistries were implemented with such backbone N-substituents, including the ring-closing metathesis, lactamization, and thiol alkylation. The backbone N-modification method was also applied to the synthesis of α-helical peptides by linking N-substituents to the peptide N-terminus, thus featuring hydrogen-bond surrogate structures. Overall, the strategy proves useful for peptide backbone macrocyclization approaches that show promise in peptide drug discovery.