1,2-dimethylquinazolin-4(1H)-one

Base Information

• Chemical Name: 1,2-dimethylquinazolin-4(1H)-one
• CAS No.: 7471-65-0
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.202
• Hs Code.: 2933990090
• NSC Number: 401263
• DSSTox Substance ID: DTXSID40322450
• Nikkaji Number: J2.368.919G
• Wikidata: Q82081021
• Mol file: 7471-65-0.mol

Synonyms:1,2-dimethylquinazolin-4(1H)-one;7471-65-0;1,2-dimethylquinazolin-4-one;glomerin;DTXSID40322450;1,2-Dimethyl-4(1H)-quinazolinone;NSC401263;4(1H)-quinazolinone, 1,2-dimethyl-;NSC 401263;NSC-401263;1,2-dimethyl-1,4-dihydroquinazolin-4-one

Chemical Property of 1,2-dimethylquinazolin-4(1H)-one

Chemical Property:

• Vapor Pressure: 0.000957mmHg at 25°C
• Boiling Point: 303°Cat760mmHg
• Flash Point: 137°C
• PSA: 34.89000
• Density: 1.18g/cm³
• LogP: 1.24190
• Storage Temp.: 2-8°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 174.079312947
• Heavy Atom Count: 13
• Complexity: 260

Purity/Quality:

1,2-Dimethylquinazolin-4(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=O)C2=CC=CC=C2N1C

Technology Process of 1,2-dimethylquinazolin-4(1H)-one

There total 8 articles about 1,2-dimethylquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

3--5-methyl-1,2,4-oxadiazole (70997-34-1) → Glomerin (7471-65-0) + 1,4-Dihydro-4-imino-1,2-dimethylchinazolin (94078-77-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 45 ℃;

Reference yield:

3--5-methyl-1,2,4-oxadiazole (70997-34-1) → Glomerin (7471-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / H₂ / 8percent Pd/C / ethanol / 45 °C

2: 1percent HCl / 1 h / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

1,2-Dimethyl-1H-quinazoline-4-thione (85690-45-5) → Glomerin (7471-65-0)

Guidance literature:

With water; silica gel; nickel; Yield given. Multistep reaction. Yields of byproduct given; 1.) ethanol, reflux;

upstream raw materials:

2-methylaminobenzamide

acetic anhydride

1,4-Dihydro-4-imino-1,2-dimethylchinazolin

1,2-Dimethyl-1H-quinazoline-4-thione