2-(Methylamino)benzamide

Base Information

• Chemical Name: 2-(Methylamino)benzamide
• CAS No.: 7505-81-9
• Molecular Formula: C8H10N2O
• Molecular Weight: 150.18
• Hs Code.: 2924299090
• European Community (EC) Number: 674-129-1
• NSC Number: 401247
• DSSTox Substance ID: DTXSID70226018
• Nikkaji Number: J1.410.276K
• Wikidata: Q83105262
• Mol file: 7505-81-9.mol

Synonyms:2-(Methylamino)benzamide;7505-81-9;2-Methylaminobenzamide;Benzamide, 2-(methylamino)-;Benzamide, o-(methylamino)-;o-(Methylamino)benzamide;BRN 2208134;2-Methylamino-benzenecarboxamide;Benzamide,2-(methylamino)-;NSC401247;Maybridge1_001680;2-carbamoyl-N-methylaniline;2-(Methylamino)benzamide #;Oprea1_192072;SCHEMBL704708;HMS546E08;DTXSID70226018;MFCD00025469;2-(Methylamino)benzamide, AldrichCPR;AKOS001045115;FS-1550;NSC 401247;NSC-401247;SB76220;LS-27173;CS-0151026;FT-0636515;EN300-06923;D70954;A838313;Z56947598

Chemical Property of 2-(Methylamino)benzamide

Chemical Property:

• Vapor Pressure: 0.000302mmHg at 25°C
• Melting Point: 161 °C
• Refractive Index: 1.619
• Boiling Point: 321.2 °C at 760 mmHg
• PKA: 15.82±0.50(Predicted)
• Flash Point: 148.1 °C
• PSA: 55.12000
• Density: 1.177 g/cm³
• LogP: 1.60050
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly)
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 147

Purity/Quality:

97% ^*data from raw suppliers

2-(Methylamino)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=CC=CC=C1C(=O)N
• Uses: 2-(Methylamino)benzamide can be used used as a plant growth regulator additive.

Technology Process of 2-(Methylamino)benzamide

There total 23 articles about 2-(Methylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-Methylisatoic anhydride (10328-92-4) → 2-methylaminobenzamide (7505-81-9)

Guidance literature:

With ammonium hydroxide; In acetonitrile; at 20 ℃;

DOI:10.1021/acs.joc.9b02771

Reference yield: 91.0%

anthranilic acid amide (28144-70-9,88-68-6) + carbonic acid dimethyl ester (616-38-6) → 2-(dimethylamino)benzamide (56042-77-4) + 2-methylaminobenzamide (7505-81-9)

Guidance literature:

With sodium-exchanged Y-zeolite; at 90 ℃; for 22h;

DOI:10.1021/jo034548a

Reference yield: 83.0%

isatoic anhydride (118-48-9) + methyl iodide (74-88-4) → 2-methylaminobenzamide (7505-81-9)

Guidance literature:

isatoic anhydride; methyl iodide; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃;

With ammonia; In water; N,N-dimethyl-formamide; at 50 ℃; for 0.5h;

DOI:10.1016/j.tet.2014.09.057

upstream raw materials:

Glycorin

anthranilic acid amide

methyl iodide

isatoic anhydride

Downstream raw materials:

arborine

glycosmicine

Glomerin

N-methyl-N-phenylacetyl-anthranilic acid amide