Technology Process of (2S,4aα)-Decahydro-8α,8aα-dimethyl-α-methylene-4-oxo-2α-naphthaleneacetic acid
There total 15 articles about (2S,4aα)-Decahydro-8α,8aα-dimethyl-α-methylene-4-oxo-2α-naphthaleneacetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
85758-24-3
1,2,3,4,4a,5,6,7,8,8a-decahydro-8β-hydroxy-4β,4aβ-dimethyl-8aβ-naphthalen-6β-ylpropenal
- Guidance literature:
-
With
jones reagent;
In
acetone;
for 6h;
Ambient temperature;
-
-
85758-14-1
1,2,3,4,4a,5,6,7,8,8a-decahydro-4β,4aβ-dimethyl-8-oxo-8aα-6-naphthylacraldehyde
- Guidance literature:
-
With
jones reagent;
In
acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 81 percent / hydrogen peroxide, aq. 6M sodium hydroxide / methanol / 1.) 15 deg C, 1 h, 2.) room temperature, 3 h
2: 71 percent / potassium hydroxide / methanol / 24 h / Heating
3: 1.) toluene-p-sulphonylhydrazine, 2.) methyl-lithium / 1.) ethanol, reflux, 1.5 h, 2.) ether, reflux, 1.5 h
4: 19 percent / lithium thiophenoxide, cuprous iodide / diethyl ether; hexane / 1.) -78 deg C, 1 h, 2.) -40 deg C, 4 h
5: Jones reagent / acetone
With
potassium hydroxide; sodium hydroxide; copper(l) iodide; jones reagent; methyllithium; dihydrogen peroxide; lithium thiophenoxide; toluene-4-sulfonic acid hydrazide;
In
methanol; diethyl ether; hexane; acetone;
