4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine

Base Information

• Chemical Name: 4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine
• CAS No.: 844694-83-3
• Molecular Formula: C17H25NO2
• Molecular Weight: 275.391
• DSSTox Substance ID: DTXSID50470638
• Wikidata: Q82298790
• Mol file: 844694-83-3.mol

Synonyms:844694-83-3;4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine;4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidine;5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane (Donepezil Impurity);SCHEMBL8243145;DTXSID50470638;CS-0241915;FT-0667246;5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane;EN300-24120705;Z3301411511;5,6-Dimethoxy-2-[(4-piperidyl)methyl]indane(donepezil impurity)

Chemical Property of 4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine

Chemical Property:

• Boiling Point: 403.1±45.0 °C(Predicted)
• PKA: 10?+-.0.10(Predicted)
• PSA: 30.49000
• Density: 1.048±0.06 g/cm3(Predicted)
• LogP: 3.13710
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 275.188529040
• Heavy Atom Count: 20
• Complexity: 283

Purity/Quality:

99.0% Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C2CC(CC2=C1)CC3CCNCC3)OC

Technology Process of 4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine

There total 1 articles about 4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5,6-dimethoxy-3-(pyridine-4-yl)spiro[indene-2,2'-oxiran]-1(3H)-one → 4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine (844694-83-3) + debenzyldonepezil (120014-30-4)

Guidance literature:

With perchloric acid; palladium 10% on activated carbon; hydrogen; In methanol; at 70 - 75 ℃; for 7h; under 4413.43 - 5149.01 Torr;

DOI:10.1248/cpb.58.1157

Reference yield:

4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine (844694-83-3) → 5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride (1034439-43-4)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane;

DOI:10.1021/jm8001313

Downstream raw materials:

5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride

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