5,6-DiMethoxy-2-[(4-piperidyl)Methyl]indane Hydrochloride (Donepezil IMpurity)

Base Information

• Chemical Name: 5,6-DiMethoxy-2-[(4-piperidyl)Methyl]indane Hydrochloride (Donepezil IMpurity)
• CAS No.: 1034439-43-4
• Molecular Formula: C17H26ClNO2
• Molecular Weight: 311.84684
• Mol file: 1034439-43-4.mol

Synonyms:5,6-DiMethoxy-2-[(4-piperidyl)Methyl]indane Hydrochloride (Donepezil IMpurity);Piperidine, 4-[(2,3-dihydro-5,6 -diMethoxy-1H-inden-2-yl) Methyl]-, hydrochloride;4-[(2,3-Dihydro-5,6-dimethoxy-1H-inden-2-yl)methyl]piperidine hydrochloride (1:1)

Chemical Property of 5,6-DiMethoxy-2-[(4-piperidyl)Methyl]indane Hydrochloride (Donepezil IMpurity)

Chemical Property:

• PSA: 30.49000
• LogP: 3.93910
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane, DMSO, Methanol

Purity/Quality:

99.0% Min ^*data from raw suppliers

5,6-Dimethoxy-2-[(4-piperidyl)methyl]indaneHydrochloride(DonepezilImpurity) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Donepezil.

Technology Process of 5,6-DiMethoxy-2-[(4-piperidyl)Methyl]indane Hydrochloride (Donepezil IMpurity)

There total 2 articles about 5,6-DiMethoxy-2-[(4-piperidyl)Methyl]indane Hydrochloride (Donepezil IMpurity) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5,6-dimethoxy-2-[(pyridin-4-yl)methylene]-1-indanone (4803-74-1) → 5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride (1034439-43-4)

Guidance literature:

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; In methanol; at 65 ℃; for 480h; under 22801.5 Torr;

DOI:10.1021/jm8001313

Reference yield:

4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine (844694-83-3) → 5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride (1034439-43-4)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane;

DOI:10.1021/jm8001313

Reference yield: 53.0%

5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride (1034439-43-4) + benzaldehyde (100-52-7) → 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindane (844694-84-4)

Guidance literature:

With sodium cyanoborohydride; In methanol; acetic acid; at 20 ℃; for 16h;

DOI:10.1021/jm8001313

upstream raw materials:

4-((5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl)piperidine

5,6-dimethoxy-2-[(pyridin-4-yl)methylene]-1-indanone

Downstream raw materials:

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1034439-43-4 5,6-DiMethoxy-2-[(4-piperidyl)Methyl]indane Hydrochloride (Donepezil IMpurity)

Send

Send

Metric Ton KG G Pound L ML

Send

Send