Tert-butyl 2-fluoro-6-formylphenylcarbamate

Base Information

• Chemical Name: Tert-butyl 2-fluoro-6-formylphenylcarbamate
• CAS No.: 844891-30-1
• Molecular Formula: C12H14FNO3
• Molecular Weight: 239.246
• Hs Code.: 2924299090
• European Community (EC) Number: 632-893-3
• DSSTox Substance ID: DTXSID50467740
• Nikkaji Number: J2.132.245H
• Wikidata: Q82294801
• Mol file: 844891-30-1.mol

Synonyms:844891-30-1;tert-Butyl (2-fluoro-6-formylphenyl)carbamate;TERT-BUTYL 2-FLUORO-6-FORMYLPHENYLCARBAMATE;(2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-butyl N-(2-fluoro-6-formylphenyl)carbamate;SCHEMBL2968874;DTXSID50467740;OGTSMYJQTZJPRZ-UHFFFAOYSA-N;MFCD11506021;AB64121;AMY202003241;CS-0341606;tert-Butyl(2-fluoro-6-formylphenyl)carbamate;D86996;EN300-318081;(2-Fluoro-6-formyl-phenyl)-carbamic acid t-butyl ester;Z1505697923

Chemical Property of Tert-butyl 2-fluoro-6-formylphenylcarbamate

Chemical Property:

• PSA: 55.40000
• LogP: 3.05820
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 239.09577147
• Heavy Atom Count: 17
• Complexity: 288

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl N-(2-fluoro-6-formylphenyl)carbamate 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1=C(C=CC=C1F)C=O

Technology Process of Tert-butyl 2-fluoro-6-formylphenylcarbamate

There total 4 articles about Tert-butyl 2-fluoro-6-formylphenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2-fluorophenylcarbamate (98968-72-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → tert-butyl N-(2-formyl-6-fluorophenyl)carbamate (844891-30-1)

Guidance literature:

tert-butyl 2-fluorophenylcarbamate; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; pentane; at -78 - 20 ℃;

Reference yield:

2-Fluoroaniline (348-54-9) → tert-butyl N-(2-formyl-6-fluorophenyl)carbamate (844891-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 85 percent / toluene / Heating

2.1: tert-butyllithium / tetrahydrofuran; pentane / -50 °C

2.2: 72 percent / tetrahydrofuran; pentane / -50 - 25 °C

With tert.-butyl lithium; In tetrahydrofuran; toluene; pentane;

DOI:10.1002/ejoc.200600118

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(2-formyl-6-fluorophenyl)carbamate (844891-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 85 percent / toluene / Heating

2.1: tert-butyllithium / tetrahydrofuran; pentane / -50 °C

2.2: 72 percent / tetrahydrofuran; pentane / -50 - 25 °C

With tert.-butyl lithium; In tetrahydrofuran; toluene; pentane;

DOI:10.1002/ejoc.200600118

upstream raw materials:

tert-butyl 2-fluorophenylcarbamate

N,N-dimethyl-formamide

2-Fluoroaniline

di-tert-butyl dicarbonate

Downstream raw materials:

C₁₆H₁₆FN

{2-Fluoro-6-[(1S,4R)-4,7,7-trimethyl-3-oxo-bicyclo[2.2.1]hept-(2E)-ylidenemethyl]-phenyl}-carbamic acid tert-butyl ester

{2-[(5S,8R,9S,10S,13S,14S)-10,13-Dimethyl-17-oxo-1,4,5,6,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-(16E)-ylidenemethyl]-6-fluoro-phenyl}-carbamic acid tert-butyl ester

2-amino-3-fluorobenzaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 844891-30-1 (2-FLUORO-6-FORMYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send