98968-72-0

Usage

Uses

Used in Pharmaceutical Industry:
N-BOC-2-Fluoroaniline is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of biologically active compounds. The BOC protective group allows for selective reactions, which is essential in the intricate processes of drug synthesis, ensuring the production of desired medicinal agents with specific therapeutic properties.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, N-BOC-2-Fluoroaniline serves as an intermediate in the production of agrochemicals, aiding in the creation of compounds that can be used in pest control and crop protection. N-BOC-2-FLUOROANILINE's reactivity, controlled by the BOC group, is vital for synthesizing effective and targeted agrochemicals.
Used in Research and Development:
N-BOC-2-Fluoroaniline is also utilized extensively in research and development processes within the pharmaceutical industry. It is a valuable building block for scientists and researchers working on the synthesis of new drugs and exploring the compound's potential interactions and effects at the molecular level, thereby contributing to the advancement of medical and chemical knowledge.

Upstream product

• 348-54-9 2-Fluoroaniline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 

Downstream Products

• 908600-92-0 (2-fluoro-6-iodophenyl)carbamic acid tert-butyl ester 
• 141940-30-9 2-(tert-Butoxycarbonylamino)-3-fluoro-benzoic acid 
• 1186637-34-2 2-(tert-butoxycarbonylamino)-3-fluorophenylboronic acid 
• 1326714-59-3 3-bromo-2-tert-butylsulfanyl-4-iodobenzaldehyde oxime 
• 1326714-58-2 3-bromo-2-tert-butylsulfanyl-4-iodobenzaldehyde 
• 1326714-57-1 3-bromo-2-fluoro-4-iodobenzaldehyde 
• 851368-08-6 1-bromo-2-fluoro-6-iodobenzene 
• 1057720-25-8 (2-bromo-6-fluoro-phenyl)-carbamic acid tert-butyl ester 
• 144851-60-5 6-fluoro-2-methylthioaniline 
• 138344-06-6 (2-tert-Butoxycarbonylamino-3-fluoro-phenyl)-acetic acid 
• 71294-03-6 7-fluoro-1,3-dihydro-indol-2-one 
• 317-20-4 7-fluoro-1H-indole-2,3-dione 
• 854538-94-6 2-amino-3-fluorobenzaldehyde 
• 854539-01-8 {2-[(5S,8R,9S,10S,13S,14S)-10,13-Dimethyl-17-oxo-1,4,5,6,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-(16E)-ylidenemethyl]-6-fluoro-phenyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

GALNAC-TGFBR1 INHIBITOR CONJUGATES FOR THE TREATMENT OF LIVER DISEASES

Conjugates comprising GalNAc moiety and a TGFβR1 inhibitor are provided. In some embodiments, the conjugates are useful for the treatment of viral infections, cancer, and fibrosis.

Palladium-Catalyzed Decarboxylative Synthesis of Arylamines

A novel approach has been developed for the synthesis of arylamines via the palladium-catalyzed intramolecular decarboxylative coupling (IDC) of aroyloxycarbamates, obtained in situ by reacting aryl carboxylic acids with hydroxycarbamates. The reaction offers facile access to structurally diverse arylamines with the site-specific formation of the C(sp2)-N bond under mild conditions.

A suitable hydrobromidum fertile for method for synthesizing west sandbank industrial production (by machine translation)

The invention provides a novel method for preparing vortioxetine hydrobromide, and belongs to the technical field of medicine synthesis. The method uses 2-fluoroaniline as a starting material to prepare the clinical medicinal vortioxetine hydrobromide by Boc protection, condensation, deprotection condensation, cyclization and other 4 steps of reaction. The method has the advantages of easy obtained raw material, low price, simple synthesis operation, mild reaction condition, easy control, no high pressure, good reaction selectivity, high yield and suitability for industrial production.

Ligand-Promoted Meta-C-H Arylation of Anilines, Phenols, and Heterocycles

Here we report the development of a versatile 3-acetylamino-2-hydroxypyridine class of ligands that promote meta-C-H arylation of anilines, heterocyclic aromatic amines, phenols, and 2-benzyl heterocycles using norbornene as a transient mediator. More than 120 examples are presented, demonstrating this ligand scaffold enables a wide substrate and coupling partner scope. Meta-C-H arylation with heterocyclic aryl iodides as coupling partners is also realized for the first time using this ligand. The utility for this transformation for drug discovery is showcased by allowing the meta-C-H arylation of a lenalidomide derivative. The first steps toward a silver-free protocol for this reaction are also demonstrated.

MUTANT IDH1 INHIBITORS USEFUL FOR TREATING CANCER

Compounds of Formula I and Formula II and the pharmaceutically acceptable salts thereof are disclosed The variables A, B, Y, Z, X1, X2, R1-4 and R13-18 are disclosed herein. The compounds are useful for treating cancer disorders, especially those involving mutant IDH1 enzymes. Pharmaceutical compositions containing compounds of Formula I or Formula II and methods of treatment comprising administering compounds of Formula I and Formula II are also disclosed.

Homogenous suspension of immunopotentiating compounds and uses thereof

The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.

Palladium-catalyzed annulation of haloanilines and halobenzamides using norbornadiene as an acetylene synthon: A route to functionalized indolines, isoquinolinones, and indoles

A general procedure for the palladium-catalyzed annulation of substituted haloanilines with norbornadiene gives functionalized indolines in 51-98% yield. These indolines can be rapidly converted to benzenoid- substituted indoles and tricyclic indolines. Extension to the use of substituted halobenzamides gives functionalized isoquinolinones in up to 86% yield.

COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is -CR4=CR5.

Palladium-catalyzed aryl amination-heck cyclization cascade: A one-flask approach to 3-substituted indoles

(Chemical Equation Presented) Two for the price of one: A Pd/dppf-based catalyst provides access to the title compounds from 1,2-dihalogenated aromatic compounds and allylic amines in a single reaction flask. The initial aryl amination step occurs with excellent selectivity for the aryl iodide to ensure the formation of a single indole regioisomer, which can be functionalized in situ by N-arylation (see scheme). dba = dibenzylideneacetone, dppf = 1,1′-bis(diphenylphospanyl)ferrocene.

Nucleus- and side-chain fluorinated 3-substituted indoles by a suitable combination of organometallic and radical chemistry

Regioselectively fluoro-, trifluoromethyl- and trifluoromethoxy-substituted 3-methyleneindolines have been prepared using a four-step procedure involving metalation/bromination of fluorinated Boc-protected anilines, N-propargylation of the resulting o-bro