Sildenafil Aldehyde IMpurity

Base Information

• Chemical Name: Sildenafil Aldehyde IMpurity
• CAS No.: 845302-49-0
• Molecular Formula: C17H22N4O2
• Molecular Weight: 314.387
• Mol file: 845302-49-0.mol

Synonyms:

Chemical Property of Sildenafil Aldehyde IMpurity

Chemical Property:

• PSA: 82.50000
• LogP: 3.32110

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Sildenafil Aldehyde IMpurity

There total 2 articles about Sildenafil Aldehyde IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-ethoxylbenzaldehyde (613-69-4) + 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide (139756-02-8) → C17H22N4O2 (845302-49-0)

Guidance literature:

With dipotassium peroxodisulfate; In ethanol; at 100 ℃; Sealed tube; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.04.051

Reference yield: 85.0%

2-ethoxylbenzaldehyde (613-69-4) + 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide (139756-02-8) → C17H22N4O2 (845302-49-0) + 5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one (139756-21-1)

Guidance literature:

With dipotassium peroxodisulfate; In water; dimethyl sulfoxide; at 80 ℃; for 0.0833333h; Solvent; Time; Sealed tube; Microwave irradiation;

DOI:10.1016/j.ejmech.2014.04.051

Reference yield: 93.5%

C17H22N4O2 (845302-49-0) → 5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one (139756-21-1)

Guidance literature:

With iron(III) chloride; oxygen; In isopropyl alcohol; at 55 - 65 ℃; for 3h;

upstream raw materials:

2-ethoxylbenzaldehyde

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

Downstream raw materials:

5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidine-7-one

5-(5-Chlorosulphonyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Refernces

• 1、 Reddy, G. Lakshma,Guru, Santosh Kumar,Srinivas,Pathania, Anup Singh,Mahajan, Priya,Nargotra, Amit,Bhushan, Shashi,Vishwakarma, Ram A.,Sawant, Sanghapal D.. "Synthesis of 5-substituted-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors". . p. 201 - 208. Retrieved 2014/05/20.