6-chloro-N,N-dimethylpyridine-2-carboxamide

Base Information

• Chemical Name: 6-chloro-N,N-dimethylpyridine-2-carboxamide
• CAS No.: 845306-05-0
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.625
• DSSTox Substance ID: DTXSID501263143
• Mol file: 845306-05-0.mol

Synonyms:6-chloro-N,N-dimethylpyridine-2-carboxamide;845306-05-0;6-chloro-N,N-dimethylpicolinamide;6-chloro-N,N-dimethyl-2-pyridinecarboxamide;2-Pyridinecarboxamide, 6-chloro-N,N-dimethyl-;SCHEMBL9319745;DTXSID501263143;BBL032337;MFCD13176450;STL372715;AKOS011515586;SB53149;VS-11173;CS-0207889

Chemical Property of 6-chloro-N,N-dimethylpyridine-2-carboxamide

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 184.0403406
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

6-chloro-N,N-dimethylpyridine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C)C(=O)C1=NC(=CC=C1)Cl

Technology Process of 6-chloro-N,N-dimethylpyridine-2-carboxamide

There total 4 articles about 6-chloro-N,N-dimethylpyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-Chloro-6-dimethylaminomethylpyridine (63763-80-4) → 6-chloro-N,N-dimethylpicolinamide (845306-05-0)

Guidance literature:

With Eosin Y; In acetonitrile; at 20 ℃; regioselective reaction; Irradiation;

DOI:10.1016/j.tetlet.2019.151041

Reference yield: 52.0%

2-chloro-1-ethoxypyridin-1-ium tetrafluoroborate + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-chloro-N,N-dimethylpicolinamide (845306-05-0) + N,N-dimethyl-2-chloro-pyridine-4-carboxamide (209262-63-5)

Guidance literature:

With dipotassium peroxodisulfate; 3-(diphenylphosphoryl)-6-methoxy-1-methylquinolin-2(1H)-one; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 21h; regioselective reaction; Sealed tube; Inert atmosphere; Irradiation;

DOI:10.1021/jacs.9b02013

Reference yield:

2-chloropyridine-N-oxide (2402-95-1) → 6-chloro-N,N-dimethylpicolinamide (845306-05-0) + N,N-dimethyl-2-chloro-pyridine-4-carboxamide (209262-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: 3-(diphenylphosphoryl)-6-methoxy-1-methylquinolin-2(1H)-one; dipotassium peroxodisulfate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 21 h / 20 °C / Sealed tube; Inert atmosphere; Irradiation

With dipotassium peroxodisulfate; 3-(diphenylphosphoryl)-6-methoxy-1-methylquinolin-2(1H)-one; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jacs.9b02013

upstream raw materials:

2-chloropyridine-N-oxide

N,N-dimethyl-formamide

2-Chloro-6-dimethylaminomethylpyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 845306-05-0 6-Chloro-N,N-dimethylpyridine-2-carboxamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send