(R)-N-Boc-1,2,3,4-tetrahydro-3-isoquinolinylmethanol

Base Information

Chemical Name:(R)-N-Boc-1,2,3,4-tetrahydro-3-isoquinolinylmethanol
CAS No.:845543-81-9
Molecular Formula:C15H21NO3
Molecular Weight:263.33200
Hs Code.:
Mol file:845543-81-9.mol

Synonyms:N-Boc-(R)-1-(1,2,3,4-tetrahydroisoquinolin-3-yl)methanol;(R)-tert-butyl 3-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate;

Suppliers and Price of (R)-N-Boc-1,2,3,4-tetrahydro-3-isoquinolinylmethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Acrotein
(R)-2-Boc-1,3,4-trihydro-3-isoquinolinemethanol 97%
1g
$ 220.00

ACHEMBLOCK
(R)-2-Boc-1,3,4-trihydro-3-isoquinolinemethanol 95%
5G
$ 810.00

ACHEMBLOCK
(R)-2-Boc-1,3,4-trihydro-3-isoquinolinemethanol 95%
1G
$ 270.00

Total 3 raw suppliers

Chemical Property of (R)-N-Boc-1,2,3,4-tetrahydro-3-isoquinolinylmethanol

Chemical Property:

PSA：49.77000
LogP:2.27860

Purity/Quality:

98% ^*data from raw suppliers

(R)-2-Boc-1,3,4-trihydro-3-isoquinolinemethanol 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-N-Boc-1,2,3,4-tetrahydro-3-isoquinolinylmethanol

There total 6 articles about (R)-N-Boc-1,2,3,4-tetrahydro-3-isoquinolinylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 78879-20-6,144069-68-1,115962-35-1
D-N-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolinoline-3-carboxylic acid

: 845543-81-9
tert-butyl (3R)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: D-N-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolinoline-3-carboxylic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 3.16667h;

With sodium hydroxide; water; In ethyl acetate;

Reference yield: 24.0%

: 312639-49-9,189563-75-5
N-Boc-(D)-Tic methyl ester

: 845543-81-9
tert-butyl (3R)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With lithium aluminium tetrahydride; at 0 - 20 ℃; for 18h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 845543-81-9
tert-butyl (3R)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water; 1,4-dioxane / 144 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 0 °C

With sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; water;