(S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Base Information

Chemical Name:(S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CAS No.:78879-20-6
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:29334900
European Community (EC) Number:833-552-3
Nikkaji Number:J1.231.502C
ChEMBL ID:CHEMBL1505896

Synonyms:Boc-Tic-OH;78879-20-6;(S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;(3S)-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;(S)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;MLS000080285;(S)-2-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;SMR000038109;11592-35-1;(3S)-2-[(Tert-Butoxy)Carbonyl]-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid;Boc-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;Boc-L-Tic-OH;N-Boc-L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid;MFCD00143845;Boc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;Boc-L-TicOH;Maybridge1_008840;(3S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;(3S)-2-tert-butoxycarbonyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;SCHEMBL66871;cid_664088;CHEMBL1505896;BDBM93566;HMS566J18;HFPVZPNLMJDJFB-LBPRGKRZSA-N;HMS2279M13;AMY29177;AR3038;CCG-55234;AKOS015892636;AC-9996;CS-W002429;(3S)-2-[(2-methylpropan-2-yl)oxy-oxomethyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;(S)-(+)-2-(tertButoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid;(S)-(+)-2-(Tertutoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid;Boc-Tic-OH, >=97.0% (TLC);BP-10136;CS-17309;B4501;EN300-154275;SR-01000644270-1;BRD-K91868689-001-07-8;(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-BOC protected;(S)-()-N-BOC-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID;(S)-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester;N-tert-Butyloxycarbonyl-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;(S)-2-tert-Butoxycarbonyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid;(S)-N-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid;(s)-n-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid;2-(t-butyloxycarbonyl)-1,2,3,4-tetrahydro-isoquinoline-3(S)-carboxylic acid

Suppliers and Price of (S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
(S)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid >98.0%(HPLC)(T)
25g
$ 258.00

TCI Chemical
(S)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid >98.0%(HPLC)(T)
5g
$ 87.00

SynQuest Laboratories
(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid, N-Boc protected 98%
5 g
$ 18.00

Matrix Scientific
Boc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
5g
$ 17.00

Labseeker
(S)-()-N-BOC-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLICACID 95
25g
$ 236.00

Frontier Specialty Chemicals
N-Boc-(S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid 98%
1g
$ 216.00

ChemScene
(S)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid 99.07%
100g
$ 130.00

ChemScene
(S)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylicacid 99.07%
500g
$ 570.00

Chem-Impex
Boc-(3)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid ≥ 98% (HPLC)
5G
$ 10.00

Chem-Impex
Boc-(3S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid,98%(HPLC) 98%(HPLC)
100G
$ 95.20

Total 65 raw suppliers

Chemical Property of (S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Chemical Property:

Appearance/Colour:white to light beige powder
Vapor Pressure:1.97E-08mmHg at 25°C
Melting Point:125-126.5 °C
Refractive Index:1.5080 (estimate)
Boiling Point:437.6 °C at 760 mmHg
PKA:3.88±0.20(Predicted)
Flash Point:218.5 °C
PSA：66.84000
Density:1.222 g/cm³
LogP:2.37090
Storage Temp.:2-8°C
Solubility.:soluble in Methanol
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:277.13140809
Heavy Atom Count:20
Complexity:388

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid >98.0%(HPLC)(T) ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC2=CC=CC=C2CC1C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N1CC2=CC=CC=C2C[C@H]1C(=O)O
Uses Boc-Tic-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Technology Process of (S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

There total 13 articles about (S)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 74163-81-8
L-Tic-OH

: 115962-35-1,144069-68-1,78879-20-6
(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 144h;

Reference yield: 98.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 103733-65-9
(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 78879-20-6,144069-68-1,115962-35-1
D-N-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolinoline-3-carboxylic acid

Guidance literature:: di-tert-butyl dicarbonate; (3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 12h;

With hydrogenchloride; In water; ethyl acetate; pH=~ 2;