N-4-Biphenylylbenzenesulfonamide

Base Information

• Chemical Name: N-4-Biphenylylbenzenesulfonamide
• CAS No.: 13607-48-2
• Molecular Formula: C18H15 N O2 S
• Molecular Weight: 309.389
• Mol file: 13607-48-2.mol

Synonyms:Benzenesulfonanilide,4'-phenyl- (6CI,8CI); NSC 95766

Chemical Property of N-4-Biphenylylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 1.5E-09mmHg at 25°C
• Refractive Index: 1.7000 (estimate)
• Boiling Point: 484.7°Cat760mmHg
• Flash Point: 247°C
• PSA: 54.55000
• Density: 1.268g/cm³
• LogP: 5.30820

Purity/Quality:

99% ^*data from raw suppliers

N-4-BIPHENYLYLBENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-4-Biphenylylbenzenesulfonamide

There total 6 articles about N-4-Biphenylylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-phenyl-4-nitrobenzene (92-93-3) + sodium benzenesulfonate (873-55-2) → N-([1,1'-biphenyl]-4-yl)benzenesulfonamide (13607-48-2)

Guidance literature:

With palladium on activated carbon; In dimethyl sulfoxide; at 120 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c8ob02226g

Reference yield: 65.0%

1-phenyl-4-nitrobenzene (92-93-3) + phenylboronic acid (98-80-6) → N-([1,1'-biphenyl]-4-yl)benzenesulfonamide (13607-48-2)

Guidance literature:

With potassium pyrosulfite; tetrabutyl-ammonium chloride; potassium carbonate; In acetonitrile; at 130 ℃; for 24h; Sealed tube;

Reference yield: 53.0%

benzenesulfonamide (98-10-2) + 2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (144432-80-4) → N-([1,1'-biphenyl]-4-yl)benzenesulfonamide (13607-48-2)

Guidance literature:

With copper diacetate; boric acid; In acetonitrile; at 80 ℃; for 24h; Molecular sieve; Sealed tube;

DOI:10.1021/jacs.6b12800

upstream raw materials:

4-phenylalanine

benzenesulfonyl chloride

benzenesulfonamide

2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

N-[2-(1-acetyl-2-oxo-propyl)-biphenyl-4-yl]-benzenesulfonamide

4-benzenesulfonylamino-biphenyl-2-carbonitrile

N-(2-hydroxy-biphenyl-4-yl)-benzenesulfonamide

3-acetoxy-6-benzenesulfonylimino-3-phenyl-cyclohexa-1,4-diene

Refernces

• 1、 -. "Method for coupling nitroaromatic compound and boric acid compound to synthesize sulfonamide compound". Paragraph 0077-0081. . Retrieved 2019/11/12.
• 2、 Vantourout, Julien C.,Miras, Haralampos N.,Isidro-Llobet, Albert,Sproules, Stephen,Watson, Allan J. B.. "Spectroscopic Studies of the Chan-Lam Amination: A Mechanism-Inspired Solution to Boronic Ester Reactivity". supporting information. p. 4769 - 4779. Retrieved 2017/04/11.