2',3'-Dideoxyguanosine

Base Information

• Chemical Name: 2',3'-Dideoxyguanosine
• CAS No.: 85326-06-3
• Molecular Formula: C10H13N5O3
• Molecular Weight: 251.245
• Hs Code.: 29339900
• Mol file: 85326-06-3.mol

Synonyms:Dideoxyguanosine;

Chemical Property of 2',3'-Dideoxyguanosine

Chemical Property:

• Boiling Point: 632.1 °C at 760 mmHg
• PKA: 9?+-.0.20(Predicted)
• Flash Point: 336.1 °C
• PSA: 119.05000
• Density: 1.91 g/cm³
• LogP: -0.04710
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2',3'-Didioxyguanosine 98% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2’-3’-Dideoxyguanosine is modified and evaluated for their anti-HIV activities and cytotoxicity in cell-based assays.

Technology Process of 2',3'-Dideoxyguanosine

There total 30 articles about 2',3'-Dideoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(9-(5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide (85326-13-2) → 2',3'-dideoxyguanosine (85326-06-3)

Guidance literature:

With ammonia; In methanol; at 50 - 55 ℃; for 12h; in a pressure vessel;

DOI:10.1021/jo00270a036

Reference yield: 87.0%

2-propionamido-9-(2',3'-dideoxy-5'-O-propionyl-β-D-ribofuranosyl)guanine → 2',3'-dideoxyguanosine (85326-06-3)

Guidance literature:

With methylamine; In ethanol; at 20 ℃; for 5h;

DOI:10.1002/cjoc.201300440

Reference yield: 77.0%

2-Amino-9-[(2R,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one (177779-53-2) → 2',3'-dideoxyguanosine (85326-06-3)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; pyridine; overnight;

DOI:10.1080/07328319608002035

upstream raw materials:

N-(9-(5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Acetic acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3-methoxythiocarbonyloxy-tetrahydro-furan-2-ylmethyl ester

2,2-Dimethyl-propionic acid (2R,3S,5R)-5-(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-3-methoxythiocarbonyloxy-tetrahydro-furan-2-ylmethyl ester

2-Amino-9-[(2R,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-1,9-dihydro-purin-6-one

Downstream raw materials:

2-amino-1,9-dihydro-6H-purin-6-one

2,3-Didesoxy-β-D-glycero-pentofuranose

C₃₁H₃₁N₅O₅

C₃₇H₃₉N₅O₈