1-(tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

Chemical Name:1-(tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.:221243-82-9
Molecular Formula:C₁₉H₁₉N₅
Molecular Weight:317.393
Hs Code.:
DSSTox Substance ID:DTXSID00274446
Nikkaji Number:J1.083.591G
Wikidata:Q27123369
Pharos Ligand ID:P1PL1HQ2D3AQ
Metabolomics Workbench ID:58220
ChEMBL ID:CHEMBL264406
Mol file:221243-82-9.mol

Synonyms:1-NA-PP1 compound;1-tert-butyl-3-naphthalen-1-ylpyrazolo(3,4-d)pyrimidin-4-amine

Suppliers and Price of 1-(tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
1-Naphthyl PP1
10mg
$ 593.00

TRC
4-Amino-1-tert-butyl-3-(1’-naphthyl)pyrazolo[3,4-d]pyrimidine
50mg
$ 700.00

Tocris
1-NaphthylPP1 ≥99%(HPLC)
50
$ 1184.00

SynChem
4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYL)PYRAZOLO[3,4-D]PYRIMIDINE 95%
10 mg
$ 120.00

Medical Isotopes, Inc.
4-Amino-1-tert-butyl-3-(1?-naphthyl)pyrazolo[3,4-d]pyrimidine
10 mg
$ 875.00

DC Chemicals
1-NA-PP1 >98%
100 mg
$ 450.00

DC Chemicals
1-NA-PP1 >98%
1 g
$ 1600.00

DC Chemicals
1-NA-PP1 >98%
250 mg
$ 800.00

Crysdot
1-NaphthylPP1 98+%
100mg
$ 693.00

Crysdot
1-NaphthylPP1 98+%
50mg
$ 409.00

Total 26 raw suppliers

Chemical Property of 1-(tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Chemical Property:

Appearance/Colour:White cyrstalline solid
Vapor Pressure:3.14E-11mmHg at 25°C
Melting Point:219-222 °C
Refractive Index:1.688
Boiling Point:527.8 °C at 760 mmHg
Flash Point:273 °C
PSA：69.62000
Density:1.27 g/cm³
LogP:4.56490
Storage Temp.:Store at +4°C
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:317.16404563
Heavy Atom Count:24
Complexity:448

Purity/Quality:

99%, ^*data from raw suppliers

1-Naphthyl PP1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC4=CC=CC=C43)N

Technology Process of 1-(tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 12 articles about 1-(tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 862728-61-8
3-bromo-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 13922-41-3
1-Naphthylboronic acid

: 221243-82-9
1-(tert-butyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; Reflux; Inert atmosphere;
DOI:10.1039/c6md00675b

Reference yield:

: 221242-71-3
2-(methoxy-naphthalen-1-yl-methylene)-malononitrile

: 221243-82-9
1-(tert-butyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / ethanol / 1 h / Heating

2: 12 h / 180 °C

With triethylamine; In ethanol;
DOI:10.1021/ja983267v

Reference yield:

: C₁₅H₁₂N₂O

: 7400-27-3
tertbutylhydrazine hydrochloride

: 77287-34-4,77287-35-5,60100-09-6
formamide

: 221243-82-9
1-(tert-butyl)-3-(1-naphthyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: C₁₅H₁₂N₂O; tertbutylhydrazine hydrochloride; With triethylamine; In ethanol; for 3.5h; Reflux;

formamide; In ethanol; Reflux;