3-Bromo-1-tert-butyl-1H-pyrazolo-[3,4-d]pyrimidin-4-amine

Base Information

• Chemical Name: 3-Bromo-1-tert-butyl-1H-pyrazolo-[3,4-d]pyrimidin-4-amine
• CAS No.: 862728-61-8
• Molecular Formula: C9H12BrN5
• Molecular Weight: 270.132
• Hs Code.: 2933990090
• Mol file: 862728-61-8.mol

Synonyms:3-bromo-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;3-bromo-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine;bromotertbutylpyrazolodpyrimidinamine;

Chemical Property of 3-Bromo-1-tert-butyl-1H-pyrazolo-[3,4-d]pyrimidin-4-amine

Chemical Property:

• PSA: 69.62000
• LogP: 2.50720

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-3-bromo-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-1-tert-butyl-1H-pyrazolo-[3,4-d]pyrimidin-4-amine

There total 2 articles about 3-Bromo-1-tert-butyl-1H-pyrazolo-[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (862728-60-7) → 3-bromo-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (862728-61-8)

Guidance literature:

With bromine; In water; at 0 ℃; Reflux;

DOI:10.1039/c6md00675b

Reference yield:

5-amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile (158001-28-6) → 3-bromo-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (862728-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.5 h / 180 °C / Microwave irradiation; Inert atmosphere

2: bromine / water / 2 h / 20 - 100 °C

With bromine; In water;

DOI:10.1016/j.tetlet.2011.08.103

Reference yield: 85.0%

3-bromo-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (862728-61-8) + 4-Chlorophenylboronic acid (1679-18-1) → PP2 (172889-27-9)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In toluene; at 100 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.08.103

upstream raw materials:

1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

5-amino-1-(tert-butyl)-1H-pyrazole-4-carbonitrile

Downstream raw materials:

1-tert-butyl-3-phenoxy-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

1-tert-butyl-3-(3-trifluoromethyl-phenylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

4-Amino-3-(4-chlorophenyl)pyrazolo<3,4-d>pyrimidine

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