Chemical Property of Lobeline, (+)-
Chemical Property:
- Vapor Pressure:3.05E-10mmHg at 25°C
- Melting Point:130-131°
- Refractive Index:1.5614 (estimate)
- Boiling Point:485.6oC at 760 mmHg
- PKA:14.34±0.20(Predicted)
- Flash Point:247.5oC
- PSA：40.54000
- Density:1.085g/cm3
- LogP:4.17390
- XLogP3:3.8
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:6
- Exact Mass:337.204179104
- Heavy Atom Count:25
- Complexity:412
- Purity/Quality:
-
98% *data from raw suppliers
Lobelin ≥98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
23/24/25
- Safety Statements:
36/37/39-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CN1C(CCCC1CC(=O)C2=CC=CC=C2)CC(C3=CC=CC=C3)O
- Isomeric SMILES:CN1[C@H](CCC[C@H]1CC(=O)C2=CC=CC=C2)C[C@H](C3=CC=CC=C3)O
- Recent ClinicalTrials:To Assess the Safety and Tolerability of 7.5, 15 and 30 mg of Sublingual Lobeline. - 1
-
Description
Lobeline is mainly present in Lobelia chinensis, Lobelia inflata, Campanula
medium, Lobelia hassleri, and Lobelia nicotianaefolia . Lobelia inflata has also
been considered as an Indian tobacco and has been used for the treatment of respiratory diseases for a long history. It was also a treatment of asthma by American
Aborigines. In the United States during the nineteenth century, doctors use Lobelia
inflata as a vomiting agent, to remove the poison from the body. It is also called
“vomit grass.” Now Lobelia inflata is still used to clear throat, bronchial, lung, and
other respiratory mucus .
-
Physical properties
Appearance: White crystalline or granular powder, odorless, and bitter. Solubility:
Soluble in ethanol or chloroform, slightly soluble in water. Melting point:
130–131?°C.
-
Uses
Lobeline is the principal lobelia alkaloid.It occurs in the seeds and herb of Indiantobacco (Lobelia inflata and Lobeliaceae). Itis used as a respiratory stimulant. Its sulfatesalt is used in antismoking tablets.
-
Indications
Lobeline was recorded in chemical drug and preparations as lobeline hydrochloride,
which is prepared as injection for the treatment of central respiratory inhibition
induced by a variety of reasons. In addition, it is also used for the treatment of neonatal stasis, carbon monoxide, opioid poisoning, and so on.
-
Clinical Use
It is mainly used in the treatment of (1) neonatal asphyxia, (2) suffocation caused by
carbon monoxide, (3) poisoning induced by inhalation of anesthetics and other central inhibitors (such as opioids and barbiturates), and (4) respiratory failure caused
by pneumonia, diphtheria, and other infectious diseases.
