UREA-13C

Base Information

• Chemical Name: UREA-13C
• CAS No.: 58069-82-2
• Molecular Formula: CH4N2O
• Molecular Weight: 61.0446
• Hs Code.: 31021000
• Mol file: 58069-82-2.mol

Synonyms:Urea-13C(7CI);Urea-13C, Research grade, 99 atom% 13C;Urea-13C USP(CRM standard);Urea-13C, UBT Grade;Urea-13C - Research Grade;

Chemical Property of UREA-13C

Chemical Property:

• Melting Point: 132-135 °C(lit.)
• Refractive Index: 1.468
• PSA: 69.11000
• Density: 1.212 g/cm³
• LogP: 0.42440
• Storage Temp.: 15-25°C
• Solubility.: DMSO (Soluble), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Urea-13C ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Labelled Urea. Physiological regulator of nitrogen excretion in mammals; synthesized in the liver as an end-product of protein catabolism and excreted in urine. Also occurs normally in skin. Emollient; diuretic.

Technology Process of UREA-13C

There total 5 articles about UREA-13C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

potassium <13C>cyanate → 13C urea (58069-82-2)

Guidance literature:

With ammonium sulfate; ammonium hydroxide; at 70 ℃; for 4h;

DOI:10.1002/(SICI)1099-1344(199612)38:12<1133::AID-JLCR935>3.0.CO;2-#

Reference yield: 47.0%

trichloro[13C]methyl phenyl sulfide (1071435-30-7) → 13C urea (58069-82-2) + (13C)-guanidine hydrochloride (286013-04-5)

Guidance literature:

trichloro[13C]methyl phenyl sulfide; With ammonia; In ethanol; dichloromethane; water; at -80 - 20 ℃; for 72.5h;

With hydrogenchloride; water;

Reference yield:

<13CO>-N-methyl-N-nitrosourea (MNU) → diazomethane (186581-53-3,908094-01-9,334-88-3) + 13C urea (58069-82-2) + carbonic acid monomethyl ester (7456-87-3) + [13C]cyanic acid (118832-13-6) + carbonate ion + (13)CH2NO5P(2-)

Guidance literature:

With sodium hydroxide; phosphate buffer; In methanol; water; at 22 ℃; Product distribution; other reagents, temperature;

DOI:10.1016/S0040-4020(97)00018-5

upstream raw materials:

trichloro[13C]methyl phenyl sulfide

Downstream raw materials:

[2-13C]-uracil

carbon dioxide

[¹³C]cyanuric acid

Refernces

• 1、 Whaley,Ott. "". . p. 167,169, 170. Retrieved 1975.
• 2、 Golding, Bernard T.,Bleasdale, Christine,McGinnis, Joseph,Mueller, Susanna,Rees, Hue Thu,Rees, Nicholas H.,Farmer, Peter B.,Watson, William P.. "The mechanism of decomposition of N-methyl-N-nitrosourea (MNU) in water and a study of its reactions with 2'-deoxyguanosine, 2'-deoxyguanosine 5'-monophosphate and d(GTGCAC)". . p. 4063 - 4082. Retrieved 2007/10/03.