Fipexide hydrochloride

Base Information

Chemical Name:Fipexide hydrochloride
CAS No.:34161-23-4
Molecular Formula:C20H21 Cl N2 O4 . Cl H
Molecular Weight:425.312
Hs Code.:
European Community (EC) Number:251-856-9
NSC Number:758407
UNII:NQ702L425I
DSSTox Substance ID:DTXSID6047446
Wikidata:Q27284990
ChEMBL ID:CHEMBL1377408
Mol file:34161-23-4.mol

Synonyms:Fipexide hydrochloride;34161-23-4;Fipexide HCl;Vigilor;Attentil;Fipexidum hydrochloride;Fipexide (hydrochloride);BP 662;EINECS 251-856-9;UNII-NQ702L425I;DTXSID6047446;NQ702L425I;NCGC00095024-01;Piperazine, 1-((p-chlorophenoxy)acetyl)-4-piperonyl-, monohydrochloride;1-(1,3-Benzodioxol-5-ylmethyl)-4-((4-chlorophenoxy)acetyl)piperazine hydrochloride;1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-chlorophenoxy)ethanone;hydrochloride;Piperazine, 1-(1,3-benzodioxol-5-ylmethyl)-4-((4-chlorophenoxy)acetyl)-, monohydrochloride;DTXCID4027446;1-(1,3-Benzodioxol-5-ylmethyl)-4-((4-chlorophenoxy)acetyl)piperazinium chloride;1-(1,3-benzodioxol-5-ylmethyl)-4-[(4-chlorophenoxy)acetyl]piperazinium chloride;SR-01000806671;CAS-34161-23-4;C20H21ClN2O4.HCl;Prestwick_601;C20H21ClN2O4.ClH;MLS002154256;SCHEMBL467102;SPECTRUM1503222;CHEMBL1377408;HY-B1124A;HMS1568L18;HMS1922K07;Pharmakon1600-01503222;FIPEXIDE HYDROCHLORIDE [MI];Tox21_111394;Tox21_302469;BP-662;CCG-39316;NSC758407;s6478;AKOS040745038;FIPEXIDE HYDROCHLORIDE [MART.];Tox21_111394_1;FIPEXIDE HYDROCHLORIDE [WHO-DD];NCGC00016825-06;NCGC00095024-02;NCGC00256757-01;SMR001233517;Fipexide hydrochloride, analytical standard;LS-110313;CS-0013606;J-019471;SR-01000806671-3;SR-01000806671-4;Q27284990;1-(4-CHLOROPHENOXYACETYL)-4-PIPERONYLPIPERAZINE HYDROCHLORIDE;1-(2-[4-Chlorophenoxy]acetyl)-4-(3,4-methylenedioxybenzyl)piperazine HCl;ETHANONE, 1-(4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL)-2-(4-CHLOROPHENOXY)-, HYDROCHLORIDE (1:1)

Suppliers and Price of Fipexide hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Fipexide hydrochloride
50mg
$ 45.00

Sigma-Aldrich
Fipexide hydrochloride analytical standard
5 g
$ 48.10

American Custom Chemicals Corporation
FIPEXIDE HYDROCHLORIDE 95.00%
10MG
$ 150.15

Total 9 raw suppliers

Chemical Property of Fipexide hydrochloride

Chemical Property:

Vapor Pressure:1.53E-12mmHg at 25°C
Melting Point:230-232°
Boiling Point:559.3 °C at 760 mmHg
Flash Point:292.1 °C
PSA：51.24000
Density:1.342g/cm³
LogP:3.46970
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:424.0956626
Heavy Atom Count:28
Complexity:492

Purity/Quality:

99% ^*data from raw suppliers

Fipexide hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C(=O)COC4=CC=C(C=C4)Cl.Cl
Uses Fipexide Hydrochloride is one of five potential drug candidates to overcome the melphalan-induced vascular toxicity.

Technology Process of Fipexide hydrochloride

There total 2 articles about Fipexide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 4122-68-3
4-chlorophenyloxyacetyl chloride

: 55436-41-4
1,4-bis-(3,4-methylenedioxybenzyl) piperazine

: 34161-23-4
1-(3',4'-methylenedioxybenzyl)-4-(4-chlorophenoxyacetyl)-piperazine hydrochloride

Guidance literature:: With sodium hydrogencarbonate; In benzene; for 7h; Heating;

Reference yield:

: 20850-43-5
5-(chloromethyl)-1,3-benzodioxole

: 34161-23-4
1-(3',4'-methylenedioxybenzyl)-4-(4-chlorophenoxyacetyl)-piperazine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / cetyltrimethylammonium bromide / H₂O / 1 h / 130 °C

2: 60 percent / NaHCO₃ / benzene / 7 h / Heating

With cetyltrimethylammonim bromide; sodium hydrogencarbonate; In water; benzene;