4122-68-3

Basic information

• Product Name: 4-CHLOROPHENOXYACETYL CHLORIDE
• Synonyms: 4-CHLOROPHENOXYACETYL CHLORIDE;TIMTEC-BB SBB009959;p-chlorophenoxyacetyl chloride;4-Chlorophenoxyacetyl chloride, tech., 90%;4-CHLOROPHENOXYACETYL CHLRORIDE;4-Chlorophenoxyacetyl chloride,90%,tech.;NSC 20549;4-Chlorophenoxyacetyl chloride 98%
• CAS NO: 4122-68-3
• Molecular Formula: C₈H₆Cl₂O₂
• Molecular Weight: 205.04
• EINECS: 223-923-2
• Product Categories: Biochemistry;Nucleosides, Nucleotides & Related Reagents;Protecting Agents for Hydroxyl and Amino Groups;Protecting Agents, Phosphorylating Agents & Condensing Agents;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 4122-68-3.mol
• Article Data: 43

Chemical Properties

• Melting Point: 18.8 °C(lit.)
• Boiling Point: 142 °C17 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: clear colorless to yellow liquid
• Density: 1.314 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00965mmHg at 25°C
• Refractive Index: n20/D 1.5486(lit.)
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Moisture Sensitive
• BRN: 609718
• CAS DataBase Reference: 4-CHLOROPHENOXYACETYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROPHENOXYACETYL CHLORIDE(4122-68-3)
• EPA Substance Registry System: 4-CHLOROPHENOXYACETYL CHLORIDE(4122-68-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 23-26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 4122-68-3(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to yellow liquid

Uses

4-Chlorophenoxyacetyl chloride was used in the preparation of:substituted acetophenone derivatives2-(4-chlorophenoxyacetylamino)-3-ethoxycarbonyl[2,3-b]quinuclidine2-(4-chlorophenoxy)-N′-[2-(4-chlorophenoxy)acetyl]acetohydrazide monohydrate

InChI:InChI=1/C8H6Cl2O2/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2

Upstream product

• 4841-22-9 (4-chloro-phenoxy)-acetic acid methyl ester 
• 106-48-9 4-chloro-phenol 
• 79-11-8 chloroacetic acid 
• 14426-42-7 ethyl p-chlorophenoxyacetate 
• 36304-28-6 tert-butyl 2-(4-chlorophenoxy)acetate 
• 1193-00-6 sodium 4-chlorophenolate 
• 122-88-3 4-Chlorophenoxyacetic acid 

Downstream Products

• 403-98-5 (4-chloro-phenoxy)-acetic acid-(3-trifluoromethyl-anilide) 
• 7462-17-1 2-(4-chlorophenoxy)-N-(2-hydroxyethyl)acetamide 
• 62095-40-3 (4-chloro-phenoxy)-acetic acid-(4-chloro-phenyl ester) 
• 221148-11-4 (4-chloro-phenoxy)-ketene 
• 72192-42-8 2-(4-chlorophenoxy)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide 
• 123529-83-9 3-(4-chlorophenoxyacetyl)-thiazolidine-2-thione 
• 113982-21-1 1-[2-(4-Chloro-phenoxy)-acetyl]-pyrrolidin-2-one 
• 201860-74-4 3,4,5-Tris-O-[(4-chlorophenoxy)acetyl]-6-O-{2,7-dibromo-9-[3-(trifluoromethyl)phenyl]xanthen-9-yl}-2-O-(4-methoxytetrahydropyran-4-yl)-L-myo-inositol 

Relevant articles and documents

A Convenient One-Pot Synthesis of 1,5-Disubstituted Tetrazoles Containing an Amino or a Carboxy Group

Abstract: A convenient method is proposed for constructing the tetrazole ring by a one-pot reaction of amides with phosphorus oxychloride and sodium azide. A series of 1,5-disubstituted tetrazoles containing an amino or a carboxy group, which present interest as buildings blocks for the synthesis of biologically active substances, were obtained.

A meclofenoxate hydrochloride preparation method

The invention discloses a meclofenoxate hydrochloride of the preparation method, comprises the following steps: (A) will acid with thionyl chloride in chlorobenzene acyl chloride reaction, to obtain the chlorophenoxy acetyl chloride; (B) step (A) to get chlorophenoxy acetyl chloride and dimethyl amino ethanol by condensation reaction to obtain the meclofenoxate free alkali; (C) step (B) to obtain the free base of the salt-forming acid salt, thermal insulation and filtering to obtain the hydrochloride. The invention easy availability of raw materials, the reaction temperature is low, the operation is convenient, the crude product of high purity, stable quality, the present invention provides a more easy operation, more environmentally friendly, more economic meclofenoxate hydrochloride synthetic pathway.

Esterquat herbicidal ionic liquids (HILs) with two different herbicides: Evaluation of activity and phytotoxicity

Herbicidal ionic liquids (HILs) constitute a new concept in crop protection products. Their main advantage is the potential to combine the efficiency of traditional herbicides with low vapour pressure and adjustable water solubility which leads to improved environmental safety in the agricultural sector. Among many strategies to obtain new HILs, esterquats seem to be well suited for modification since both the cation and anion may be constituents of herbicides. In the framework of this study 16 new esterquat HILs were synthetized based on standard herbicides: 2,4-D, MCPA, MCPP, 4-CPA, Clopyralid and Dicamba. Germination tests performed on agricultural soil using cornflower indicated the best two HILs. Furthermore, analysis of the toxicological effects of HILs on wheat plants revealed an additional advantage of the two selected HILs. The glutathione (GSH) content and glutathione S-transferase (GST) activity showed a lower oxidative stress level in wheat plants treated with examined HILs, respectively, in comparison to a mixture of reference compounds. Finally the Ames test was applied in order to analyse the mutagenic activity of the two selected HILs.