AKOS AKM00108

Base Information

• Chemical Name: AKOS AKM00108
• CAS No.: 4480-47-1
• Molecular Formula: C6H10O2
• Molecular Weight: 114.144
• Hs Code.: 2914400090
• Mol file: 4480-47-1.mol

Synonyms:tert-Butylglyoxal;3,3-dimethyl-2-oxobutyraldehyde;3,3-dimethyl-2-oxo-butanal;3,3-dimethylbutan-1,2-dione;t-Butylglyoxal;

Chemical Property of AKOS AKM00108

Chemical Property:

• Vapor Pressure: 10.8mmHg at 25°C
• Boiling Point: 128.2°C at 760 mmHg
• Flash Point: 34.4°C
• PSA: 34.14000
• Density: 0.935g/cm³
• LogP: 0.80050

Purity/Quality:

99%, ^*data from raw suppliers

AKOSAKM00108 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS AKM00108

There total 9 articles about AKOS AKM00108 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,3-dimethyl-butan-2-one (75-97-8) → t-butylglyoxal (4480-47-1)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; water; Heating;

DOI:10.1016/j.bmcl.2008.02.037

Reference yield: 90.5%

1,1-dichloro-3,3-dimethylbutan-2-one (22591-21-5) → t-butylglyoxal (4480-47-1)

Guidance literature:

With sodium carbonate; dimethyl sulfoxide; at 80 ℃; for 2h; Reagent/catalyst; Temperature;

Reference yield:

1-(1-methyl-1H-imidazol-2-yl)ethan-1-one (85692-37-1) → (1-methyl-2-imidazolyl)glyoxal (109991-16-4) + t-butylglyoxal (4480-47-1)

Guidance literature:

upstream raw materials:

3,3-dimethyl-butan-2-one

3,3-dimethylbutyrylaldehyde

1-Bromopinacolon

selenium(IV) oxide

Downstream raw materials:

2-hydroxy-1-mesityl-3,3-dimethyl-butan-1-one

1-hydroxy-1-mesityl-3,3-dimethyl-butan-2-one

7-tert-Butyl-1,3-dimethyllumazin

8-Benzyl-2-tert-butyl-6-(4-hydroxy-phenyl)-7H-imidazo[1,2-a]pyrazin-3-one

Refernces

• 1、 De Bruin, Bas,De Zwart, Felix J.,Li, Zirui,Mathew, Simon,Wolzak, Lukas A.,Zhou, Minghui. "Catalytic Synthesis of 1 H-2-Benzoxocins: Cobalt(III)-Carbene Radical Approach to 8-Membered Heterocyclic Enol Ethers". supporting information. p. 20501 - 20512. Retrieved 2021/12/03.
• 2、 Goti, Giulio,Bieszczad, Bartosz,Vega-Pe?aloza, Alberto,Melchiorre, Paolo. "Stereocontrolled Synthesis of 1,4-Dicarbonyl Compounds by Photochemical Organocatalytic Acyl Radical Addition to Enals". supporting information. p. 1213 - 1217. Retrieved 2019/01/04.