2-methylflavinantine

Base Information

• Chemical Name: 2-methylflavinantine
• CAS No.: 23979-25-1
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 23979-25-1.mol

Synonyms:(+)-O-Methylflavinanthine;(+)-O-Methylflavinantine; (9R)-Sebiferine; O-Methylflavinantine; Sebiferine

Chemical Property of 2-methylflavinantine

Chemical Property:

• Vapor Pressure: 6.04E-11mmHg at 25°C
• Boiling Point: 520.8°C at 760 mmHg
• Flash Point: 268.8°C
• PSA: 48.00000
• Density: 1.26g/cm³
• LogP: 2.17910

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: This alkaloid has been isolated from the non-phenolic fraction of the ethanolic extract of the trunk bark of Litsea sebiferea. The structure has been established by chemical and spectroscopic methods.

Technology Process of 2-methylflavinantine

There total 5 articles about 2-methylflavinantine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (9R)-(+)-norsebiferine → O-methylflavinantine (23979-25-1,121822-42-2,20948-08-7)

Guidance literature:

With formic acid; for 10h; Heating;

DOI:10.1016/0957-4166(95)00213-9

Reference yield:

(9R)-(-)-N-trifluoroacetylnorsebiferine (169304-63-6) → O-methylflavinantine (23979-25-1,121822-42-2,20948-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / aq.K₂CO₃ / methanol / 5 h / Heating

2: 44 percent / 85percent HCO₂H / 10 h / Heating

With formic acid; potassium carbonate; In methanol;

DOI:10.1016/0957-4166(95)00213-9

Reference yield:

2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (102922-34-9) + formyl acetic anhydride (2258-42-6) + 4-chloromethyl-1,2-dimethoxy-benzene (7306-46-9) → O-methylflavinantine (23979-25-1,121822-42-2,20948-08-7) + 9-S-O-methylflavinantine (22169-18-2,23979-25-1,27510-33-4,121822-42-2,20948-08-7)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4039(00)80079-9

upstream raw materials:

2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

formyl acetic anhydride

4-chloromethyl-1,2-dimethoxy-benzene

formaldehyd