THIOSALICYLIC ACID SODIUM SALT

Base Information

• Chemical Name: THIOSALICYLIC ACID SODIUM SALT
• CAS No.: 134-23-6
• Molecular Formula: C7H6 O2 S . Na
• Molecular Weight: 176.171
• Hs Code.: 2930909090
• Mol file: 134-23-6.mol

Synonyms:Benzoicacid, 2-mercapto-, monosodium salt (9CI); Benzoic acid, o-mercapto-, monosodiumsalt (8CI); 2-Mercaptobenzoic acid sodium salt; Sodium 2-mercaptobenzoate;Sodium thiosalicylate; Thiocyl; Thiosal; Thiosalicylic acid, sodium salt;o-Mercaptobenzoic acid, sodium salt

Chemical Property of THIOSALICYLIC ACID SODIUM SALT

Chemical Property:

• Vapor Pressure: 0.000563mmHg at 25°C
• Melting Point: 168-169oC
• Boiling Point: 298.6°Cat760mmHg
• Flash Point: 134.4°C
• PSA: 78.93000
• Density: 1.345g/cm³
• LogP: 0.33880

Purity/Quality:

98%,99%, ^*data from raw suppliers

Sodium Thiosalicylate >95.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: complexing agent in lithiation, oxidative coupling of terminal acetylenes to diynes and with alkyllithiums in orthometallation of aromatics

Technology Process of THIOSALICYLIC ACID SODIUM SALT

There total 5 articles about THIOSALICYLIC ACID SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Thiosalicylic acid (147-93-3) → 2-sulfanylbenzoic acid, disodium salt (134-23-6,19296-18-5)

Guidance literature:

With metallic sodium; In ethanol; for 7h; Reflux;

DOI:10.1134/S1070428011030250

Reference yield:

methyl 2-(acetylthio)benzoate (152766-18-2) → sodium thiosalicylate (134-23-6)

Guidance literature:

With methanol; water; sodium hydroxide; at 80 ℃; for 4h;

Reference yield:

methyl 2-fluorobenzoate (394-35-4) → sodium thiosalicylate (134-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 12 h / 20 °C

2: methanol; water; sodium hydroxide / 4 h / 80 °C

With methanol; water; potassium carbonate; sodium hydroxide; In acetone;

upstream raw materials:

Thiosalicylic acid

methyl 2-fluorobenzoate

methyl 2-(acetylthio)benzoate

Downstream raw materials:

3-Benzothienylthiosalicylsaeure

2-((1H-indol-3-yl)thio)benzoic acid

2-(3-Methyl-benzo[f]quinolin-1-ylsulfanyl)-benzoic acid

trihexyl(tetradecyl)phosphonium thiosalicylate

Refernces

• 1、 Tokareva,Shagun,Dorofeev,Shagun,Voronkov. "Reaction of 1,3-dihalopropan-2-ones with 2-sulfanylbenzoic acid mono- and disodium salts". experimental part. p. 461 - 463. Retrieved 2011/06/26.