2,3,4,6,7,8-Hexahydro-1,3-dimethyl-8-hydroxyethyl-1H-imidazo(2,1-f)pur ine-2,4-dione

Base Information

• Chemical Name: 2,3,4,6,7,8-Hexahydro-1,3-dimethyl-8-hydroxyethyl-1H-imidazo(2,1-f)pur ine-2,4-dione
• CAS No.: 28557-24-6
• Molecular Formula: C₁₁H₁₅N₅O₃
• Molecular Weight: 265.272
• Mol file: 28557-24-6.mol

Synonyms:1-(2-Hydroxyethyl)-6,8-dimethylimidazolino[1,2-f]xanthine;KT 119

Chemical Property of 2,3,4,6,7,8-Hexahydro-1,3-dimethyl-8-hydroxyethyl-1H-imidazo(2,1-f)pur ine-2,4-dione

Chemical Property:

• Vapor Pressure: 2.68E-11mmHg at 25°C
• Boiling Point: 511.8°Cat760mmHg
• Flash Point: 263.3°C
• PSA: 85.29000
• Density: 1.63g/cm³
• LogP: -1.68900

Purity/Quality:

99% ^*data from raw suppliers

2,3,4,6,7,8-HEXAHYDRO-1,3-DIMETHYL-8-HYDROXYETHYL-1H-IMIDAZO(2,1-F)PUR INE-2,4-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,4,6,7,8-Hexahydro-1,3-dimethyl-8-hydroxyethyl-1H-imidazo(2,1-f)pur ine-2,4-dione

There total 6 articles about 2,3,4,6,7,8-Hexahydro-1,3-dimethyl-8-hydroxyethyl-1H-imidazo(2,1-f)pur ine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

8-bromo-7-(2-bromoethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione (58431-80-4) + ethanolamine (141-43-5) → dimethyl-1,3 dioxo-2,4 dihydro-6,7 (hydroxy-2 ethyl)-8 1H,3H,8H imidazo<2,1-f>purine (28557-24-6)

Guidance literature:

In ethanol; for 5h; Heating;

DOI:10.1016/S0223-5234(99)00131-2

Reference yield: 22.0%

(chloro-2 ethyl)-7 bromo-8 theophylline (31580-04-8) + ethanolamine (141-43-5) → dimethyl-1,3 dioxo-2,4 dihydro-6,7 (hydroxy-2 ethyl)-8 1H,3H,8H imidazo<2,1-f>purine (28557-24-6)

Guidance literature:

In neat (no solvent); at 120 - 210 ℃; for 0.166667h;

DOI:10.1002/jhet.5570220127

Reference yield: 11.0%

dimethyl-1,3 dioxo-2,4 dihydro-6,7 (chloro-2 ethyl)-8 1H,3H,8H imidazo<2,1-f>purine (49687-13-0) → dimethyl-1,3 dioxo-2,4 dihydro-6,7 (hydroxy-2 ethyl)-8 1H,3H,8H imidazo<2,1-f>purine (28557-24-6)

Guidance literature:

With sodium hydroxide; In ethanol; for 15h; Heating;

DOI:10.1002/jhet.5570220127

upstream raw materials:

dimethyl-1,3 dioxo-2,4 dihydro-6,7 (chloro-2 ethyl)-8 1H,3H,8H imidazo<2,1-f>purine

(chloro-2 ethyl)-7 bromo-8 theophylline

ethanolamine

8-bromo-7-(2-bromoethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

Downstream raw materials:

8-[2-(4-phenyl-1-piperazinyl)-ethyl]-1,3,6,7-tetrahydro-(8H)-imidazo[2,1-f]theophylline

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