4-Piperidinecarboxylic acid, 1-[3-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: 4-Piperidinecarboxylic acid, 1-[3-(trifluoromethyl)phenyl]-
• CAS No.: 847407-02-7
• Molecular Formula: C13H14F3NO2
• Molecular Weight: 273.255
• Mol file: 847407-02-7.mol

Synonyms:1-(3-trifluoromethylphenyl)-piperidine-4-carboxylic acid;1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxylic acid;

Chemical Property of 4-Piperidinecarboxylic acid, 1-[3-(trifluoromethyl)phenyl]-

Chemical Property:

• PSA: 40.54000
• LogP: 3.07140

Purity/Quality:

1-(3-(Trifluoromethyl)phenyl)piperidine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Piperidinecarboxylic acid, 1-[3-(trifluoromethyl)phenyl]-

There total 2 articles about 4-Piperidinecarboxylic acid, 1-[3-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

→ 1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxylic acid (847407-02-7)

Guidance literature:

Reference yield:

Methyl 1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxylate (857651-36-6) → 1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxylic acid (847407-02-7)

Guidance literature:

Methyl 1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxylate; With sodium hydroxide; water; In tetrahydrofuran; methanol; at 50 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=3;

Reference yield:

1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxylic acid (847407-02-7) + 1-(5-aminoindolin-1-yl)ethanone (4993-96-8) → 1-(3-Trifluoromethyl-phenyl)-piperidine-4-carboxylic acid (1-acetyl-2,3-dihydro-1H-indol-5-yl)-amide (888036-90-6)

Guidance literature:

DOI:10.1016/j.bmcl.2008.07.035

upstream raw materials:

Methyl 1-[3-(trifluoromethyl)phenyl]piperidine-4-carboxylate

Downstream raw materials:

tert-butyl [(3S)-1-({1-[3-(trifluoromethyl)phenyl]piperidin-4-yl}carbonyl)pyrrolidin-3-yl]carbamate

1-(3-Trifluoromethyl-phenyl)-piperidine-4-carboxylic acid (1H-indol-6-yl)-amide

1-(3-Trifluoromethyl-phenyl)-piperidine-4-carboxylic acid (1H-indol-5-yl)-amide

1-(3-Trifluoromethyl-phenyl)-piperidine-4-carboxylic acid quinolin-3-ylamide