4993-96-8

Basic information

• Product Name: 1-ACETYL-5-AMINO-2,3-DIHYDRO-(1H)-INDOLE
• Synonyms: BUTTPARK 48\08-62;1-ACETYL-5-AMINO-2,3-DIHYDRO-(1H)-INDOLE;1-ACETYLINDOLIN-5-AMINE;TIMTEC-BB SBB010097;1-Acetyl-5-aminoindoline;1-(5-amino-2,3-dihydro-1H-indol-1-yl)ethan-1-one;1-Acetylindolin-5-amine ,97%;1H-indol-5-amine, 1-acetyl-2,3-dihydro-
• CAS NO: 4993-96-8
• Molecular Formula: C₁₀H₁₂N₂O
• Molecular Weight: 176.22
• Product Categories: Indole
• Mol File: 4993-96-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 180-182
• Boiling Point: 469.7 °C at 760 mmHg
• Flash Point: 237.9 °C
• Appearance: /
• Density: 1.231 g/cm³
• Vapor Pressure: 5.38E-09mmHg at 25°C
• Refractive Index: 1.628
• PKA: 3.86±0.20(Predicted)
• CAS DataBase Reference: 1-ACETYL-5-AMINO-2,3-DIHYDRO-(1H)-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ACETYL-5-AMINO-2,3-DIHYDRO-(1H)-INDOLE(4993-96-8)
• EPA Substance Registry System: 1-ACETYL-5-AMINO-2,3-DIHYDRO-(1H)-INDOLE(4993-96-8)

Safety Data

• Hazard Codes: Xi
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• Hazardous Substances Data: 4993-96-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C10H12N2O/c1-7(13)12-5-4-8-6-9(11)2-3-10(8)12/h2-3,6H,4-5,11H2,1H3

Upstream product

• 32692-19-6 5-nitro-2,3-dihydro-1H-indole 
• 108-24-7 acetic anhydride 
• 120-72-9 indole 
• 4769-98-6 1-(5-nitro-1H-indol-1-yl)ethan-1-one 
• 33632-27-8 1-(5-nitro-2,3-dihydroindol-1-yl)ethanone 
• 496-15-1 1-indoline 
• 16078-30-1 1-Acetyl-2,3-dihydro-1H-indole 

Downstream Products

• 214698-31-4 1-ethyl-5-aminoindoline 
• 937591-32-7 1-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-indol-1-yl]ethanone 
• 1155542-49-6 N-(2,3-dihydro-1H-indol-5-yl)-C,C,C-trifluoromethanesulfonamide 
• 42443-15-2 1-(6-bromo-5-hydroxy-2,3-dihydroindol-1-yl)ethanone 
• 4770-32-5 1-(5-hydroxy-2,3-dihydroindol-1-yl)ethanone 

Relevant articles and documents

Using weak interactions to control C-H mono-nitration of indolines

An unprecedented C-H mononitration of indolines either at the -C5 or -C7 positions under mild condition is reported here. The roles of multiple weak interactions and factors such as steric factors, electronic effects, cation-π interactions, and solvent polarity were established, and we achieved a 100% regioselective electrophilic aromatic (EArS) nitration using Cu(NO3)2 or AgNO3.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

NOVEL PROTEIN TYROSINE PHOSPHATASE - IB INHIBITORS

The present invention relates to the novel compounds of the general formula (I), wherein the symbols are same as described in specification, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, to process and intermediates for the preparation of the above said compounds, having the utility of these compounds in medicine and to methods for their therapeutic use, and their use in the treatment of metabolic disorders.