2-nitro-1-(phenylsulfonyl)-4-(trifluoromethyl)benzene

Base Information

• Chemical Name: 2-nitro-1-(phenylsulfonyl)-4-(trifluoromethyl)benzene
• CAS No.: 2795-60-0
• Molecular Formula: C13H8 F3 N O4 S
• Molecular Weight: 331.2671
• Mol file: 2795-60-0.mol

Synonyms:Sulfone,phenyl a,a,a-trifluoro-2-nitro-p-tolyl (6CI,8CI);1-Phenylsulfonyl-2-nitro-4-trifluoromethylbenzene; NSC 39132; NSC 642590

Chemical Property of 2-nitro-1-(phenylsulfonyl)-4-(trifluoromethyl)benzene

Chemical Property:

• Vapor Pressure: 1.88E-07mmHg at 25°C
• Boiling Point: 437.7°Cat760mmHg
• Flash Point: 218.5°C
• Density: 1.484g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-nitro-1-(phenylsulfonyl)-4-(trifluoromethyl)benzene

There total 4 articles about 2-nitro-1-(phenylsulfonyl)-4-(trifluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

(2-nitro-4-(trifluoromethyl)phenyl)phenylthioether (346-44-1) → (2-nitro-4-trifluoromethyl-phenyl)-phenyl sulfone (2795-60-0)

Guidance literature:

With dihydrogen peroxide;

DOI:10.1021/cb500789h

Reference yield:

sodium thiophenolate (930-69-8) → (2-nitro-4-trifluoromethyl-phenyl)-phenyl sulfone (2795-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: aqueous H₂O₂; acetic acid

With ethanol; dihydrogen peroxide; acetic acid;

DOI:10.1021/jo01354a019

Reference yield:

2-chloro-3-nitro-5-trifluoromethylbenzene (121-17-5) → (2-nitro-4-trifluoromethyl-phenyl)-phenyl sulfone (2795-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: aqueous H₂O₂; acetic acid

With ethanol; dihydrogen peroxide; acetic acid;

DOI:10.1021/jo01354a019

upstream raw materials:

(2-nitro-4-(trifluoromethyl)phenyl)phenylthioether

sodium thiophenolate

2-chloro-3-nitro-5-trifluoromethylbenzene

thiophenol

Downstream raw materials:

2-benzenesulfonyl-5-trifluoromethyl-aniline