930-69-8Relevant articles and documents
Geometrically unprecedented 3-, 5- and 7-membered Hg(II)-Cu(I) and Hg(II)-Ag(I) thiolate clusters: Precursors to intermetallics
Gupta, Geetika,Chaturvedi, Jyotsna,Bhattacharya, Subrato
, p. 8932 - 8937 (2015)
The syntheses of three polynuclear heterobimetallic complexes through the use of a homoleptic mercuric thiolate anion as a template for the assembly of coinage metal are presented. The complexes, [(PPh3)3Ag3(μ-SPh)7/
A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice
Moon, Deuk Kyu,Tripathi, Abhai,Sullivan, David,Siegler, Maxime A.,Parkin, Sean,Posner, Gary H.
, p. 2773 - 2775 (2011)
Four 5-carbon-linked trioxane dimer orthoesters (6a-6d) have been prepared in 4 or 5 chemical steps from the natural trioxane artemisinin (1). When administered orally to malaria-infected mice using a single dose of only 6 mg/kg body weight along with 18
Structurally homologous sialidases exhibit a commonality in reactivity: Glycoside hydrolase-catalyzed hydrolysis of Kdn-thioglycosides
Nejatie, Ali,Akintola, Oluwafemi,Steves, Elizabeth,Shamsi Kazem Abadi, Saeideh,Moore, Margo M.,Bennet, Andrew J.
, (2020/12/07)
Aspergillus fumigatus is one of the main causative agents of invasive aspergillosis, an often-lethal fungal disease that affects immunocompromised individuals. A. fumigatus produces a sialidase that cleaves the nine-carbon carbohydrate Kdn from glycoconju
Inherent Reactivity of Spiro-Activated Electrophilic Cyclopropanes
Jüstel, Patrick M.,Ofial, Armin R.,Pignot, Cedric D.,Stan, Alexandra
supporting information, p. 15928 - 15935 (2021/10/25)
The kinetics of the ring-opening reactions of thiophenolates with geminal bis(acceptor)-substituted cyclopropanes in DMSO at 20 °C was monitored by photometric methods. The determined second-order rate constants of the SN2 reactions followed linear relationships with Mayr nucleophilicity parameters (N/sN) and Br?nsted basicities (pKaH) of the thiophenolates as well as with Hammett substituent parameters (σ) for groups attached to the thiophenolates. Phenyl-substituted cyclopropanes reacted by up to a factor of 15 faster than their unsubstituted analogues, in accord with the known activating effect of adjacent π-systems in SN2 reactions. Variation of the electronic properties of substituents at the phenyl groups of the cyclopropanes gave rise to parabolic Hammett relationships. Thus, the inherent SN2 reactivity of electrophilic cyclopropanes is activated by electron-rich π-systems because of the more advanced C1?C2 bond polarization in the transition state. On the other hand, electron-poor π-systems also lower the energetic barriers for the attack of anionic nucleophiles owing to attractive electrostatic interactions.
