Technology Process of Fluradoline
There total 6 articles about Fluradoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
ethylene glycol;
at 150 - 160 ℃;
for 1h;
DOI:10.1021/jm00179a005
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / KOH / ethanol; H2O / 3 h / Heating
2: thionyl chloride / 0.17 h / Heating
3: 80 percent / AlCl3 / 1,2-dichloro-ethane / 2 h / Heating
4: boron trifluoride / acetic acid / 1.) RT, 16 h, 2.) reflux, 30 min
5: 72 percent / K2CO3 / CH2Cl2 / 24 h / Ambient temperature
6: KOH / ethane-1,2-diol / 1 h / 150 - 160 °C
With
potassium hydroxide; aluminium trichloride; thionyl chloride; boron trifluoride; potassium carbonate;
In
ethanol; dichloromethane; water; ethylene glycol; acetic acid; 1,2-dichloro-ethane;
DOI:10.1021/jm00179a005
- Guidance literature:
-
Multi-step reaction with 3 steps
1: boron trifluoride / acetic acid / 1.) RT, 16 h, 2.) reflux, 30 min
2: 72 percent / K2CO3 / CH2Cl2 / 24 h / Ambient temperature
3: KOH / ethane-1,2-diol / 1 h / 150 - 160 °C
With
potassium hydroxide; boron trifluoride; potassium carbonate;
In
dichloromethane; ethylene glycol; acetic acid;
DOI:10.1021/jm00179a005
