Technology Process of 2-(4-fluorophenoxy)phenylacetic acid
There total 1 articles about 2-(4-fluorophenoxy)phenylacetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
ethanol; water;
for 3h;
Heating;
DOI:10.1021/jm00179a005
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride / 0.17 h / Heating
2: 80 percent / AlCl3 / 1,2-dichloro-ethane / 2 h / Heating
3: boron trifluoride / acetic acid / 1.) RT, 16 h, 2.) reflux, 30 min
4: magnesium, MeOH / 1.) 10-20 deg C, 30 min, 2.) RT, 1 h
5: 84 percent / cyanogen bromide, K2CO3 / CHCl3 / 0.17 h / Ambient temperature
6: sodium bicarbonate, KI / dimethylsulfoxide / 5 h / Ambient temperature
With
methanol; aluminium trichloride; thionyl chloride; bromocyane; boron trifluoride; sodium hydrogencarbonate; potassium carbonate; magnesium; potassium iodide;
In
chloroform; acetic acid; dimethyl sulfoxide; 1,2-dichloro-ethane;
DOI:10.1021/jm00179a005
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / 0.17 h / Heating
2: 80 percent / AlCl3 / 1,2-dichloro-ethane / 2 h / Heating
3: boron trifluoride / acetic acid / 1.) RT, 16 h, 2.) reflux, 30 min
4: 72 percent / K2CO3 / CH2Cl2 / 24 h / Ambient temperature
With
aluminium trichloride; thionyl chloride; boron trifluoride; potassium carbonate;
In
dichloromethane; acetic acid; 1,2-dichloro-ethane;
DOI:10.1021/jm00179a005
