2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 24237-44-3
• Molecular Formula: C10H14 N2 O2 S
• Molecular Weight: 226.2954
• Hs Code.: 2934999090
• Mol file: 24237-44-3.mol

Synonyms:2-Amino-3-ethoxycarbonyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine;Nor-Y 3642

Chemical Property of 2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 1.07E-07mmHg at 25°C
• Boiling Point: 432.9°Cat760mmHg
• Flash Point: 215.6°C
• PSA: 92.59000
• Density: 1.268g/cm³
• LogP: 2.06270

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-Amino-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

There total 2 articles about 2-AMINO-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

piperidin-4-one (41661-47-6) + ethyl 2-cyanoacetate (105-56-6) → ethyl 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (24237-44-3)

Guidance literature:

With sulfur; triethylamine; In water; at 20 ℃; for 2h;

DOI:10.1080/17415993.2013.860141

Reference yield:

→ ethyl 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (24237-44-3)

Guidance literature:

4-Piperidone, ethyl cyanoacetate, S, morpholine, EtOH;

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (24237-44-3) → C19H21N3O3S

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium formate / 16 h / 140 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

With ammonium formate; caesium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2016.07.009

upstream raw materials:

piperidin-4-one

ethyl 2-cyanoacetate