Benzenepropanamide, N-[(4-chlorophenyl)sulfinyl]-

Base Information

• Chemical Name: Benzenepropanamide, N-[(4-chlorophenyl)sulfinyl]-
• CAS No.: 847980-48-7
• Molecular Formula: C15H14ClNO2S
• Molecular Weight: 307.801
• Mol file: 847980-48-7.mol

Synonyms:

Chemical Property of Benzenepropanamide, N-[(4-chlorophenyl)sulfinyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanamide, N-[(4-chlorophenyl)sulfinyl]-

There total 1 articles about Benzenepropanamide, N-[(4-chlorophenyl)sulfinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

p-chlorobenzenesulphinamide (16096-86-9) + 3-phenylpropionic anhydride (15781-96-1) → N-dihydrocinnamoyl-p-chlorobenzenesulfinamide (847980-48-7)

Guidance literature:

p-chlorobenzenesulphinamide; With n-butyllithium; In tetrahydrofuran;

3-phenylpropionic anhydride; In tetrahydrofuran;

DOI:10.1021/ja045397b

Reference yield: 30.0%

N-dihydrocinnamoyl-p-chlorobenzenesulfinamide (847980-48-7) → (R)-p-chlorobenzenesulfinamide + (S)-N-dihydrocinnamoyl-p-chlorobenzenesulfinamide (847980-59-0)

Guidance literature:

With recombinant subtilisin E; In acetonitrile; at 37 ℃; for 72h; pH=8.0;

DOI:10.1021/ja045397b

Reference yield:

N-dihydrocinnamoyl-p-chlorobenzenesulfinamide (847980-48-7) → (S)-p-chlorobenzenesulfinamide

Guidance literature:

Multi-step reaction with 2 steps

1: 27 percent / recombinant subtilisin E / acetonitrile / 72 h / 37 °C / pH 8.0

2: 92 percent / hydrazine hydrate / 3 h / 20 °C

With recombinant subtilisin E; hydrazine hydrate; In acetonitrile;

DOI:10.1021/ja045397b

upstream raw materials:

p-chlorobenzenesulphinamide

3-phenylpropionic anhydride

Downstream raw materials:

(S)-N-dihydrocinnamoyl-p-chlorobenzenesulfinamide